INTERACTIONS BETWEEN CYTOKINES AND EICOSANOIDS - A STUDY USING HUMAN PERITONEAL-MACROPHAGES

被引：32

作者：

PRUIMBOOM, WM ^{[1
]}

VANDIJK, JAPM ^{[1
]}

TAK, CJAM ^{[1
]}

GARRELDS, I ^{[1
]}

BONTA, IL ^{[1
]}

WILSON, PJH ^{[1
]}

ZIJLSTRA, FJ ^{[1
]}

机构：

[1] UNIV HOSP DIJKZIGT,DEPT INTERNAL MED 2,ROTTERDAM,NETHERLANDS

来源：

IMMUNOLOGY LETTERS | 1994年 / 41卷 / 2-3期

关键词：

HUMAN PERITONEAL MACROPHAGES; EICOSANOIDS; CYTOKINES; INTERACTIONS;

D O I：

10.1016/0165-2478(94)90142-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To examine the interactions between the main proinflammatory cytokines and eicosanoids produced by human inflammatory cells, human peritoneal macrophages (hp-M phi) were isolated from ascitic fluid of patients with portal hypertension. Interactions between interleukin-1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha (TNF-alpha), leukotriene B-4 (LTB(4)) and prostaglandin E(2) (PGE(2)) were studied by addition or inhibition of several cytokines and eicosanoids: human recombinant IL-1 beta (hrIL-1 beta) addition, LTB(4) addition and 5-lipoxygenase inhibition (6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazole hydrochloride (E6080)), PGE, addition and cyclooxygenase inhibition (indomethacin). In hp-M phi hrIL-1 beta stimulated the LTB(4) production, while the PGE(2) production was inhibited. HrIL-1 beta had no significant effect on IL-6 production in hp-M phi. LTB, did not regulate IL-1 beta and IL-6 production. Increasing PGE(2) down regulated the TNF-alpha production, but did not effect the IL-1 beta and IL-6 production.

引用

页码：255 / 260

页数：6

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