LOW-DOSE CYCLOSPORINE VERSUS PLACEBO IN PATIENTS WITH RHEUMATOID-ARTHRITIS

被引:264
作者
TUGWELL, P
BOMBARDIER, C
GENT, M
BENNETT, KJ
BENSEN, WG
CARETTE, S
CHALMERS, A
ESDAILE, JM
KLINKHOFF, AV
KRAAG, GR
LUDWIN, D
ROBERTS, RS
机构
[1] MCMASTER UNIV, DEPT MED, HAMILTON L8N 3Z5, ONTARIO, CANADA
[2] CHEDOKE MCMASTER HOSP, DIV RHEUMATOL, HAMILTON L8N 3Z5, ONTARIO, CANADA
[3] WELLESLEY COLL HOSP, DEPT RHEUMATOL, TORONTO M4Y 1J3, ONTARIO, CANADA
[4] ST JOSEPHS HOSP, DIV RHEUMATOL, HAMILTON L8N 1Y4, ONTARIO, CANADA
[5] UNIV LAVAL, DEPT MED, QUEBEC CITY G1K 7P4, QUEBEC, CANADA
[6] UNIV BRITISH COLUMBIA, DEPT RHEUMATOL, VANCOUVER V6T 1W5, BC, CANADA
[7] MONTREAL GEN HOSP, DIV RHEUMATOL, MONTREAL H3G 1A4, QUEBEC, CANADA
[8] OTTAWA CIVIC HOSP, DEPT RHEUMATOL, OTTAWA, ONTARIO, CANADA
关键词
D O I
10.1016/0140-6736(90)92630-Z
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
144 patients with severe rheumatoid arthritis from six centres were randomised to receive oral cyclosporin or placebo for 6 months. The initial daily dose of cyclosporin was 2·5 mg/kg, which was increased cautiously with monitoring of serum cyclosporin levels and creatinine; the mean stabilisation dose was 3·8 mg/kg. There were significant improvements in the cyclosporin-treated patients compared with the controls in the major outcomes of reduction of active joints (23% improvement), pain (24%), and functional status (16%); global improvement was 27%. In the cyclosporin group serum creatinine increased by a mean of 15·6 μmol/l and mean arterial blood pressure by 6·27 mm Hg; these increases were controlled in all but 2 patients by dose adjustment without withdrawal from the study. © 1990.
引用
收藏
页码:1051 / 1055
页数:5
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