INFLUENCE OF NEOMYCIN AND METRONIDAZOLE ON COLONIC MICROFLORA OF VOLUNTEERS

被引：40

作者：

ARABI, Y

DIMOCK, F

BURDON, DW

ALEXANDERWILLIAMS, J

KEIGHLEY, MRB

机构：

[1] General Hospital, Birmingham

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1979年 / 5卷 / 05期

关键词：

D O I：

10.1093/jac/5.5.531

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The influence on colonic microflora of neomycin and metronidazole alone, or in combination, was studied in volunteers taking a normal diet. Bacterial counts on daily faecal samples revealed that metronidazole had no influence on anaerobic faecal bacteria. Neornycin on the other hand, was effective against sensitive aerobes. However, the combination of neomycin and metronidazole profoundly reduced both aerobic and anaerobic bacteria. Assay of faecal antibiotic concentrations showed that neomycin achieved high intraluminal levels while metronidazole was undetectable or present at low concentrations. © 1979, by The British Society for Antimicrobial Chemotherapy.

引用

页码：531 / 537

页数：7

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