DIURNAL DIFFERENCES IN OPIOID PEPTIDE LEVELS CORRELATED WITH NOCICEPTIVE SENSITIVITY

被引:95
作者
WESCHE, DL
FREDERICKSON, RCA
机构
[1] INDIANA UNIV,SCH MED,DEPT PHARMACOL,INDIANAPOLIS,IN 46202
[2] ELI LILLY & CO,LILLY RES LAB,INDIANAPOLIS,IN 46206
关键词
D O I
10.1016/0024-3205(79)90237-6
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
An increase in whole mouse brain total opioid levels, determined by mouse was deferens bioassay, was observed in mice sacrified in late afternoon (when they are least responsive to pain) compared to early morning (when they are most responsive to pain). There were no comparable increases in levels of met5- or leu5- enkephalin measured by RIA methodology. There were differences, however, in the effects of noxious stimuli on met5-enkephalin levels in the efternoon compared to the morning. In the afternoon, but not in the morning, the levels of met5-enkephalin in mice tested after hot plate stress were significantly increased compared to those of unstressed animals. Thus, there appears to be some correlation between activity in endogenous opioid systems and the ability of mice to withstand noxious stimuli. © 1979.
引用
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页码:1861 / 1867
页数:7
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