EVIDENCE FOR THE PRESENCE OF ANGIOTENSIN-II-TYPE-1 RECEPTORS IN BRAIN

被引：53

作者：

WAMSLEY, JK

HERBLIN, WF

ALBURGES, ME

HUNT, M

机构：

[1] UNIV N DAKOTA,CTR MED EDUC,DEPT NEUROSCI,DIV NEUROPHARMACOL,FARGO,ND 58102

[2] DUPONT CO,DEPT MED PROD,EXPTL STN,WILMINGTON,DE 19880

来源：

BRAIN RESEARCH BULLETIN | 1990年 / 25卷 / 03期

关键词：

AII-type; 1; receptors; 2; Angiotensin II; DUP; 753; Hypertension; Neuropeptides; Nonpeptide antihypertensive; Receptor subtypes;

D O I：

10.1016/0361-9230(90)90226-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177. Both receptor subtypes appear to exist in the brain, but the type 1 receptor predominates in the small regions of brain where AII binding is highly concentrated. DUP 753 may have a central action involved in its unique antihypertensive effect. © 1990.

引用

页码：397 / 400

页数：4

共 12 条

[1]

CHIU AT, 1989, J PHARMACOL EXP THER, V250, P867

[2]

CHIU AT, 1990, J PHARMACOL EXP THER, V252, P711

[3] IDENTIFICATION OF ANGIOTENSIN-II RECEPTOR SUBTYPES [J].