TREATMENT OF HIRSUTISM WITH THE PURE ANTIANDROGEN FLUTAMIDE

被引:98
作者
CUSAN, L
DUPONT, A
BELANGER, A
TREMBLAY, RR
MANHES, G
LABRIE, F
机构
[1] CHU LAVAL,HORMONAL BIOREGULAT LAB,QUEBEC CITY G1V 4G2,QUEBEC,CANADA
[2] CHU LAVAL,RES CTR,MOLEC ENDOCRINOL LAB,2705 LAURIER BLVD,QUEBEC CITY G1V 4G2,QUEBEC,CANADA
关键词
D O I
10.1016/0190-9622(90)70241-9
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The effectiveness of the antiandrogen flutamide in combination with an oral contraceptive was studied in 20 patients with moderate to severe hirsutism. Eight patients had no previous therapy, whereas 12 had failed to respond to oral contraceptives, spironolactone, or dexametha-sone therapy. Treatment with the antiandrogen flutamide (250 mg twice daily) and an oral contraceptive (Ortho 1/35) resulted in a particularly rapid and marked decrease in the total hirsutism score, which reached the normal range at 7 months. Seborrhea, acne, and hair loss score were also rapidly corrected. Treatment was associated with a decrease in plasma luteinizing hormone, progesterone, and estradiol levels. Plasma sex hormone-binding globulin levels were initially low in 18 of 20 patients but increased significantly during therapy. No clinically significant side effects were observed. © 1990, American Academy of Dermatology, Inc.. All rights reserved.
引用
收藏
页码:462 / 469
页数:8
相关论文
共 28 条
[1]   INHIBITION OF BASAL AND ADRENOCORTICOTROPIN-STIMULATED PLASMA-LEVELS OF ADRENAL ANDROGENS AFTER TREATMENT WITH AN ANTIANDROGEN IN CASTRATED PATIENTS WITH PROSTATIC-CANCER [J].
BELANGER, A ;
DUPONT, A ;
LABRIE, F .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 59 (03) :422-426
[2]   SIMULTANEOUS RADIOIMMUNOASSAY OF PROGESTINS, ANDROGENS AND ESTROGENS IN RAT TESTIS [J].
BELANGER, A ;
CARON, S ;
PICARD, V .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1980, 13 (02) :185-190
[3]  
BELISLE S, 1986, FERTIL STERIL, V46, P1015
[4]   FEMALE HIRSUTISM - PATHOPHYSIOLOGICAL CONSIDERATIONS AND THERAPEUTIC IMPLICATIONS [J].
BIFFIGNANDI, P ;
MASSUCCHETTI, C ;
MOLINATTI, GM .
ENDOCRINE REVIEWS, 1984, 5 (04) :498-513
[5]   ANTIANDROGENIC EFFECT OF SPIROLACTONES - MECHANISM OF ACTION [J].
CORVOL, P ;
MICHAUD, A ;
MENARD, J ;
FREIFELD, M ;
MAHOUDEAU, J .
ENDOCRINOLOGY, 1975, 97 (01) :52-58
[6]  
CREMONCINI C, 1976, ACTA EUR FERTIL, V7, P298
[7]  
DORFMAN RI, 1971, 3RD P INT C HORM STE, P995
[8]  
FAURE N, 1982, FERTIL STERIL, V37, P416
[9]   CLINICAL ASSESSMENT OF BODY HAIR GROWTH IN WOMEN [J].
FERRIMAN, D ;
GALLWEY, JD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1961, 21 (11) :1440-+
[10]   USE OF CYPROTERONE-ACETATE (CPA) IN TREATMENT OF ACNE, HIRSUTISM AND VIRILISM [J].
HAMMERSTEIN, J ;
MECKIES, J ;
LEOROSSBERG, I ;
MOLTZ, L ;
ZIELSKE, F .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1975, 6 (06) :827-836