ISOLATION OF 3 NOVEL HUMAN CYCLINS BY RESCUE OF G1 CYCLIN (CLN) FUNCTION IN YEAST

被引：826

作者：

LEW, DJ

DULIC, V

REED, SI

机构：

[1] Department of Molecular Biology, MB7 The Scripps Research Institute, La Jolla, CA 92037

来源：

CELL | 1991年 / 66卷 / 06期

关键词：

D O I：

10.1016/0092-8674(91)90042-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated a number of cDNAs derived from human mRNAs that are able to substitute for G1 cyclin genes in S. cerevisiae. Several of these encode human cyclins A, B1, and B2. Three novel genes have been identified, which we call cyclins C, D, and E. The novel proteins are sufficiently distantly related to the other members of the cyclin family and to each other as to constitute three new classes of cyclins. Cyclin C and E mRNAs accumulate periodically through the cell cycle, peaking at different times in G1.

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页码：1197 / 1206

页数：10

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