AMPICILLIN-LOADED LIPOSOMES AND NANOPARTICLES - COMPARISON OF DRUG LOADING, DRUG RELEASE AND INVITRO ANTIMICROBIAL ACTIVITY

被引：30

作者：

FATTAL, E ^{[1
]}

ROJAS, J ^{[1
]}

ROBLOTTREUPEL, L ^{[1
]}

ANDREMONT, A ^{[1
]}

COUVREUR, P ^{[1
]}

机构：

[1] FAC PHARM CHATENAY MALABRY,PHARM GALENIQUE LAB,CNRS,URA 1218,5 RUE J B CLEMENT,F-92296 CHATENAY MALABRY,FRANCE

来源：

JOURNAL OF MICROENCAPSULATION | 1991年 / 8卷 / 01期

关键词：

D O I：

10.3109/02652049109021855

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this paper, we report the physico-chemical properties of negatively charged liposomes and of polyisohexylcyanoacrylate nanoparticles loaded with ampicillin. Although the carriers were of the same size (200 nm), drug-loading capacity was 20 times higher for nanoparticles than for liposomes. After freeze-drying or storage at +4-degrees-C, no drug escaped from polymeric nanoparticles. On the other hand, in the same conditions, ampicillin leaked rapidly from liposomes. Drug release in foetal calf serum was gradual (of zero order) with nanoparticles, whereas it was rapid with liposomes. Finally, the antimicrobial activity of ampicillin-entrapped liposomes or nanoparticles was studied in vitro.

引用

页码：29 / 36

页数：8

共 14 条

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