TRANSLOCATION (14-18) AND (8-22) IN 3 PATIENTS WITH ACUTE-LEUKEMIA LYMPHOMA FOLLOWING CENTROCYTIC CENTROBLASTIC NON-HODGKINS-LYMPHOMA

被引：35

作者：

FIEDLER, W

WEH, HJ

ZELLER, W

FONATSCH, C

HILLION, J

LARSEN, C

WORMANN, B

HOSSFELD, DK

机构：

[1] MED UNIV LUBECK, DEPT HUMAN GENET, LUBECK, GERMANY

[2] INSERM, U301, DEPT MED, F-75005 PARIS, FRANCE

[3] MED UNIV CLIN MUNSTER, MUNSTER, GERMANY

来源：

ANNALS OF HEMATOLOGY | 1991年 / 63卷 / 05期

关键词：

TRANSLOCATION (14-18) AND (8-22); LEUKEMIA; NHL;

D O I：

10.1007/BF01698379

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three patients with centrocytic/centroblastic lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14;18) and t (8;22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14;18) was present during the first phase of the disease and that acquisition of translocation t (8;22) was accompanied by leukemic transformation.

引用

页码：282 / 287

页数：6

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