ALKYLPHOSPHONOUS ACID DIESTERS, NOVEL REAGENTS FOR THE OXALIMIDE CYCLIZATION TO PENEMS

被引：10

作者：

BUDT, KH

FISCHER, G

HORLEIN, R

KIRRSTETTER, R

LATTRELL, R

机构：

[1] Hoechst AG, Pharma Forschung G838

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(00)79085-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylphosphonous acid diesters MeP(OR)2 3a-b were shown to be highly effective and mild reducing reagents in the oxalimide cyclization of azetidinone-1-oxalyl-4-di- or tri-thiocarbonates or 4-thioesters 1a-t forming penems 2a-t at lower temperature, shorter reaction times, and higher yields compared to classical phosphites P(OMe)3 and P(OEt)3.

引用

页码：5331 / 5334

页数：4

共 6 条

[1] NEW SYNTHESIS OF PENEMS, THE OXALIMIDE CYCLIZATION REACTION [J].