THE ISOLATION AND STRUCTURAL ELUCIDATION OF 4 NOVEL TRITERPENE LACTONES, PSEUDOLAROLIDE-A, PSEUDOLAROLIDE-B, PSEUDOLAROLIDE-C, AND PSEUDOLAROLIDE-D, FROM PSEUDOLARIX-KAEMPFERI

被引：52

作者：

CHEN, GF

LI, ZL

PAN, DJ

TANG, CM

HE, X

XU, GY

CHEN, K

LEE, KH

机构：

[1] SHANGHAI MED UNIV, SCH PHARM, DEPT CHEM NAT DRUGS, SHANGHAI 200032, PEOPLES R CHINA

[2] ACAD SINICA, SHANGHAI INST MAT MED, SHANGHAI 200032, PEOPLES R CHINA

[3] SHANGHAI INST PHARMACEUT IND RES, SHANGHAI, PEOPLES R CHINA

[4] UNIV N CAROLINA, SCH PHARM, DIV MED CHEM & NAT PROD, NAT PROD LAB, CHAPEL HILL, NC 27599 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 07期

关键词：

D O I：

10.1021/np50097a015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four novel triterpene lactones, pseudolarolides A [1], B [2], C [3], and D [4], were isolated from the seeds of Pseudolarix kaempferi. Their structures and stereochemistry were elucidated from spectral data. Compound 2 shows potent cytotoxicity against three human cancer cell lines, KB (nasopharyngeal), A-549 (lung), and HCT-8 (colon), and against a murine leukemia cell line (P-388) with ED50 values of 0.49, 0.67, 0.73, and 0.79 mug/ml, respectively.

引用

页码：1114 / 1122

页数：9

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