INFUSION OF NEUROSTEROIDS INTO THE NUCLEUS BASALIS MAGNOCELLULARIS AFFECTS COGNITIVE-PROCESSES IN THE RAT

被引：192

作者：

MAYO, W ^{[1
]}

DELLU, F ^{[1
]}

ROBEL, P ^{[1
]}

CHERKAOUI, J ^{[1
]}

LEMOAL, M ^{[1
]}

BAULIEU, EE ^{[1
]}

SIMON, H ^{[1
]}

机构：

[1] FAC MED BICETRE,UNITE RECH COMMUN HORMONALES,INSERM,U33,LE KREMLIN BICETR,FRANCE

来源：

BRAIN RESEARCH | 1993年 / 607卷 / 1-2期

关键词：

NEUROSTEROID; MEMORY; PLACE RECOGNITION TASK; NUCLEUS BASALIS MAGNOCELLULARIS; RAT;

D O I：

10.1016/0006-8993(93)91524-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurosteroids, pregnenolone sulfate (PREG-S) and tetrahydroprogesterone (TH-PROG), act on the GABA(A) receptor with antagonist or agonist-like properties, respectively. In this study the effect of the infusion of PREG-S and TH-PROG into the nucleus basalis magnocellularis (NBM) of the rat was examined in a two-trial memory task. The results show that PREG-S (5 ng in 0.5 mul) enhances memory performance when injected after an acquisition trial; conversely TH-PROG (2 ng in 0.5 mul) disrupts performance when injected before an acquisition trial. A role for neurosteroids in memory processes subserved by the nucleus basalis magnocellularis is of interest in view of the implication of this structure and these substances in neurodegenerative processes.

引用

页码：324 / 328

页数：5

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