A FORMULATION FOR CORRELATING PROPERTIES OF PEPTIDES AND ITS APPLICATION TO PREDICTING HUMAN-IMMUNODEFICIENCY-VIRUS PROTEASE-CLEAVABLE SITES IN PROTEINS

被引：40

作者：

CHOU, JJ

机构：

[1] Department of Physics, University of Michigan, Ann Arbor, Michigan

来源：

BIOPOLYMERS | 1993年 / 33卷 / 09期

关键词：

D O I：

10.1002/bip.360330910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A mathematical frame has been established to generally formulate the correlating properties of peptides. The formulation can be used to study the specificity of multisite enzymes, particularly in predicting the susceptible sites in proteins by human immunodeficiency virus (HIV) proteases, and hence can serve as a supplementary means in designing HIV protease inhibitors as potential drugs against acquired immunodeficiency syndrome. (C) 1993 John Wiley & Sons, Inc.

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收藏

页码：1405 / 1414

页数：10

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