INDUCTION OF CISPLATINUM SENSITIVITY WITHOUT ALTERATION IN RADIATION SENSITIVITY BY FRACTIONATED RADIATION TREATMENT OF A HUMAN LARYNGEAL SQUAMOUS-CELL CARCINOMA CELL-LINE

被引：7

作者：

REDPATH, JL

HYDEN, EC

SUN, C

机构：

[1] Department of Radiation Oncology, University of California Irvine, Irvine

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1995年 / 32卷 / 03期

关键词：

CISPLATINUM SENSITIVITY; RADIATION-INDUCED; HUMAN SQUAMOUS CELL CARCINOMA;

D O I：

10.1016/0360-3016(94)00634-W

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To determine if fractionated radiation treatment can alter cisplatinum sensitivity of a human laryngeal squamous carcinoma cell line. Methods and Materials: Human squamous carcinoma cells, both previously untreated, as well as survivors of fractionated radiation therapy, were tested in vitro for their sensitivity to gamma radiation and cisplatinum. Fractionated gamma radiation was delivered in 14 or 10 daily fractions of 2 Gy. The cell line, cSCC-20, was derived from an untreated primary human laryngeal carcinoma. Results: The human laryngeal squamous cell carcinoma cell line, cSCC-20, was demonstrated to have heterogeneous subpopulations with respect to cisplatinum sensitivity. No variation in radiation sensitivity was seen among subpopulations of varying cisplatinum sensitivity. The cells were relatively radioresistant (Do = 2.5 Gy). Fractionated radiation treatments of the parent cell line (14 fractions, 14 days, 2 Gy/fraction) or a cisplatinum sensitive subline (10 fractions, 12 days, 2 Gy/fraction) induced cisplatinum sensitivity (factor of 1.3 to 1.4) in the surviving cells. Conclusion: Fractionated radiation treatment of human squamous carcinoma cells in vitro induced sensitivity to cisplatinum without concomitant alteration in radiation sensitivity.

引用

页码：681 / 685

页数：5

共 23 条

[1]

Bedford, Shellard, Walker, Whelan, Masters, Hill, Differential expression of collateral sensitivity or resistance to cisplatin in human bladder carcinoma cell lines preexposed in vitro to either X-irradiation or cisplatin, Int. J. Cancer, 40, pp. 681-686, (1986)

[2]

Bellamy, Whelan, Lock, Hill, Effects of fractionated X-irradiation on subsequent response to acute X-irradiation in two human tumor cell lines in vitro, Int. J. Radiat. Biol., 51, pp. 681-691, (1987)

[3]

Brown, Drug or radiation changes to the host which could effect the outcome of combined modality therapy, Int. J. Radiat. Oncol. Biol. Phys., 5, pp. 1151-1163, (1979)

[4]

Crooijmans, Schwachofer, Hoogenhout, The influence of pre-irradiation on the survival of two head and neck squamous cell carcinoma cell lines, Anticancer Res., 11, pp. 297-300, (1991)

[5]

Dempke, Shellard, Hosking, Fichtinger-Shepman

[6]

Hill, B. T. Mechanisms associated with the expression of cisplatin resistance in a human ovarian tumor cell line following exposure to fractionated X-irradiation in vitro, Carcinogenesis, 13, pp. 1209-1215, (1992)

[7]

Dempke, Whelan, Hill, Expression of resistance to etoposide and vincristine in vitro and in vivo after X-irradiation of ovarian tumor cells, Anticancer Drugs, 3, pp. 395-399, (1992)

[8]

Fu, Biological basis for the interaction of chemotherapeutic agents and radiotherapy, Cancer, 55, pp. 2123-2130, (1985)

[9]

Hill, Interaction between antitumor agents and radiation and the expression of resistance, Cancer Treat. REv., 18, pp. 149-190, (1991)

[10]

Hill, Bellamy, Establishment of an etoposide-resistant human epithelial cell line in vitro: Characterization of patterns of cross-resistance and drug sensitivities, Int. J. Cancer, 33, pp. 599-608, (1984)

← 1 2 3 →