ONCOGENIC ACTIVATION OF TYROSINE KINASES

被引：122

作者：

RODRIGUES, CA ^{[1
]}

PARK, M ^{[1
]}

机构：

[1] MCGILL UNIV, MONTREAL H3A 1A1, PQ, CANADA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0959-437X(94)90086-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tyrosine kinases comprise the largest group of oncoproteins, a fact that underscores the importance of reversible tyrosine phosphorylation in the regulation of essential cellular functions. Oncogenic activation of tyrosine kinases results in the constitutive activation of what is normally a conditionally regulated enzyme activity. Studies of tyrosine kinase oncoproteins, and a comparison with their corresponding proto-oncogene products, have identified important functional and regulatory domains within these proteins, positive and negative regulators of their enzyme activities and signalling cascades that control cell growth and differentiation.

引用

页码：15 / 24

页数：10

共 94 条

[1] GROWTH-FACTORS AND CANCER
AARONSON, SA
[J]. SCIENCE, 1991, 254 (5035) : 1146 - 1153
[2] ONCOGENIC ACTIVATION OF THE NEU-ENCODED RECEPTOR PROTEIN BY POINT MUTATION AND DELETION
BARGMANN, CI
WEINBERG, RA
[J]. EMBO JOURNAL, 1988, 7 (07) : 2043 - 2052
[3] BENLEVY R, 1992, J BIOL CHEM, V267, P17304
[4] THE HUMAN P50(CSK) TYROSINE KINASE PHOSPHORYLATES P56(LCK) AT TYR-505 AND DOWN REGULATES ITS CATALYTIC ACTIVITY
BERGMAN, M
MUSTELIN, T
OETKEN, C
PARTANEN, J
FLINT, NA
AMREIN, KE
AUTERO, M
BURN, P
ALITALO, K
[J]. EMBO JOURNAL, 1992, 11 (08) : 2919 - 2924
[5] BOLEN JB, 1993, ONCOGENE, V8, P2025
[6] MOLECULAR CHARACTERIZATION OF A THYROID TUMOR-SPECIFIC TRANSFORMING SEQUENCE FORMED BY THE FUSION OF RET TYROSINE KINASE AND THE REGULATORY SUBUNIT RI-ALPHA OF CYCLIC AMP-DEPENDENT PROTEIN KINASE-A
BONGARZONE, I
MONZINI, N
BORRELLO, MG
CARCANO, C
FERRARESI, G
ARIGHI, E
MONDELLINI, P
DELLAPORTA, G
PIEROTTI, MA
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (01) : 358 - 366
[7] SUBSTITUTION OF THE ERBB-2 ONCOPROTEIN TRANSMEMBRANE DOMAIN ACTIVATES THE INSULIN-RECEPTOR AND MODULATES THE ACTION OF INSULIN AND INSULIN-RECEPTOR SUBSTRATE-1
CHEATHAM, B
SHOELSON, SE
YAMADA, K
GONCALVES, E
KAHN, CR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) : 7336 - 7340
[8] NEGATIVE REGULATION OF T-CELL RECEPTOR SIGNALING BY TYROSINE PROTEIN-KINASE P50(CSK)
CHOW, LML
FOURNEL, M
DAVIDSON, D
VEILLETTE, A
[J]. NATURE, 1993, 365 (6442) : 156 - 160
[9] IDENTIFICATION OF A PROTEIN THAT BINDS TO THE SH3 REGION OF ABI AND IS SIMILAR TO BCR AND GAP-RHO
CICCHETTI, P
MAYER, BJ
THIEL, G
BALTIMORE, D
[J]. SCIENCE, 1992, 257 (5071) : 803 - 806
[10] THE WHEN AND HOW OF SRC REGULATION
COOPER, JA
HOWELL, B
[J]. CELL, 1993, 73 (06) : 1051 - 1054

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