ISOMERIC MONOACETYLMONO(1-HYDROXYETHYL)DEUTEROPORPHYRINS - SYNTHESES, CHARACTERIZATION, AND USE FOR THE SYNTHESES OF REGIOSELECTIVELY METHYL-DEUTERATED AND VINYL-DEUTERATED HEMINS

被引：19

作者：

SHIAU, FY

PANDEY, RK

RAMAPRASAD, S

DOUGHERTY, TJ

SMITH, KM

机构：

[1] ONCOL FDN BUFFALO,225 OAK ST,SUITE 200,BUFFALO,NY 14203

[2] UNIV CALIF DAVIS,DEPT CHEM,DAVIS,CA 95616

[3] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT RADIAT MED,BUFFALO,NY 14263

[4] UNIV ARKANSAS MED SCI HOSP,DEPT RADIOL,LITTLE ROCK,AR 72205

[5] UNIV ARKANSAS MED SCI HOSP,DEPT PATHOL,LITTLE ROCK,AR 72205

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 07期

关键词：

D O I：

10.1021/jo00294a039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of hematoporphyrin IX dimethyl ester (7) with tetrapropylammonium perruthenate (Prn4N)(Ru04) and N-methylmorpholine N-oxide affords a high yield of the separable monoacetylmono(1-hydroxyethyl)-deuteroporphyrin isomers 5 and 6. Proton NMR NOE experiments and chemical transformations involving specific individual deuteration at the 1- and 3-methyls and 2- and 4-vinyls are used to characterize the isomers. © 1990, American Chemical Society. All rights reserved.

引用

页码：2190 / 2195

页数：6

共 26 条

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