NEURONAL HYPERTROPHY IN THE HUMAN SUPRAOPTIC AND PARAVENTRICULAR NUCLEUS IN AGING AND ALZHEIMERS-DISEASE

被引：38

作者：

VOGELS, OJM ^{[1
]}

BROERE, CAJ ^{[1
]}

NIEUWENHUYS, R ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN,DEPT ANAT & EMBRYOL,6500 HB NIJMEGEN,NETHERLANDS

来源：

NEUROSCIENCE LETTERS | 1990年 / 109卷 / 1-2期

关键词：

Cell count; Neuronal hypertrophy; Normal aging; Alzheimer's disease; Paraventricular nucleus; Supraoptic nucleus;

D O I：

10.1016/0304-3940(90)90538-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the literature, activation of the hypothalamo-neurohypophyseal system (HNS) in normal aging has been demonstrated in rat and human. This activation might be secondary to an age-related decline in vasopressin binding sites in the kidney, or to cell loss in the supraoptic (SON) and paraventricular nuclei (PVN) and/or to an age-related decline in noradrenergic (NA) innervation of the hypothalamus. This study shows neuronal hypertrophy in SON and PVN in normal aging and an additional hypertrophy in Alzheimer's disease. No cell loss could be demonstrated in both conditions. © 1990.

引用

页码：62 / 67

页数：6

共 33 条

[1] MECHANISM OF EFFECT OF HYPOXIA ON RENAL WATER-EXCRETION [J].

ANDERSON, RJ ;

PLUSS, RG ;

BERNS, AS ;

JACKSON, JT ;

ARNOLD, PE ;

SCHRIER, RW ;

MCDONALD, KM .

JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (04) :769-777

[2]

BARGMANN WOLFGANG, 1951, AMER SCI, V39, P255

[3]

BONDAREFF W, 1981, LANCET, V1, P783

[4] THE VASOPRESSINERGIC INNERVATION OF THE BRAIN IN NORMAL AND CASTRATED RATS [J].

DEVRIES, GJ ;

BUIJS, RM ;

VANLEEUWEN, FW ;

CAFFE, AR ;

SWAAB, DF .

JOURNAL OF COMPARATIVE NEUROLOGY, 1985, 233 (02) :236-254

[5]

DIERICKX K, 1977, CELL TISSUE RES, V184, P15, DOI 10.1007/BF00220524

[6] THE VASOPRESSIN AND OXYTOCIN NEURONS IN THE HUMAN SUPRAOPTIC AND PARAVENTRICULAR NUCLEUS - CHANGES WITH AGING AND IN SENILE DEMENTIA [J].

FLIERS, E ;

SWAAB, DF ;

POOL, CW ;

VERWER, RWH .

BRAIN RESEARCH, 1985, 342 (01) :45-53

[7] ACTIVATION OF VASOPRESSINERGIC AND OXYTOCINERGIC NEURONS DURING AGING IN THE WISTAR RAT [J].

FLIERS, E ;

SWAAB, DF .

PEPTIDES, 1983, 4 (02) :165-170

[8] VASOPRESSIN AND CARDIOVASCULAR-SYSTEM IN AGING [J].

FROLKIS, VV ;

GOLOVCHENKO, SF ;

MEDVED, VI ;

FROLKIS, RA .

GERONTOLOGY, 1982, 28 (05) :290-302

[9] NOTES ON ESTIMATION OF NUMERICAL DENSITY OF ARBITRARY PROFILES - EDGE EFFECT [J].

GUNDERSEN, HJG .

JOURNAL OF MICROSCOPY-OXFORD, 1977, 111 (NOV) :219-223

[10] THE EFFICIENCY OF SYSTEMATIC-SAMPLING IN STEREOLOGY AND ITS PREDICTION [J].

GUNDERSEN, HJG ;

JENSEN, EB .

JOURNAL OF MICROSCOPY-OXFORD, 1987, 147 :229-263

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