COMPLEMENTARY OLIGONUCLEOTIDE SEQUENCE INHIBITS BOTH VMW65 GENE-EXPRESSION AND REPLICATION OF HERPES-SIMPLEX VIRUS

被引：14

作者：

DRAPER, KG ^{[1
]}

CERUZZI, M ^{[1
]}

KMETZ, ME ^{[1
]}

STURZENBECKER, LJ ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP,DEPT ANTIVIRAL CHEMOTHERAPY,BLOOMFIELD,NJ 07003

来源：

ANTIVIRAL RESEARCH | 1990年 / 13卷 / 04期

关键词：

Herpes simplex virus; Oligonucleotide inhibition;

D O I：

10.1016/0166-3542(90)90034-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The virion tegument protein, Vmw65, of herpes simplex virus is a transacting molecule which induces immediate early gene transcription. We show that an oligodeoxyribonucleotide which is complementary to the translation initiation region of Vmw65 mRNA inhibited the expression of Vmw65 biological activity in a Vmw65-expressing cell line and reduced the yield of HSV-1 in tissue culture. The levels of oligomer required to effect viral replication resulted in no observable cellular toxicity. © 1990.

引用

页码：151 / 164

页数：14

共 21 条

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