EFFECT OF METHADONE AND MORPHINE ON SEROTONIN UPTAKE IN RAT PERIAQUEDUCTAL GRAY SLICES

被引：4

作者：

DONZANTI, BA ^{[1
]}

WARWICK, RO ^{[1
]}

机构：

[1] PHILADELPHIA COLL PHARM & SCI,DEPT BIOL SCI,PHARMACOL SECT,PHILADELPHIA,PA 19104

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 1-2期

关键词：

5-HT uptake; Methadone; Morphine; Naloxone; Periaqueductal gray;

D O I：

10.1016/0014-2999(79)90030-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In vitro effects of d,1-methadone and morphine on [3H]eerotonin (3H-5-HT) uptake in rat periaqueductal gray (PAG) slices were investigated. Only methadone had a significant inhibitory effect on 3H-5-HT uptake which was significantly enhanced by naloxone. The systemic administration of methadone did not affect 3H-5-HT uptake in vitro. These data further weaken the possible relationship between narcotic analgesia and blockade of the 5-HT reuptake mechanism. © 1979.

引用

页码：107 / 110

页数：4

共 11 条

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