CHARACTERIZATION OF PEAK-E, A NOVEL AMINO-ACID ASSOCIATED WITH EOSINOPHILIA-MYALGIA-SYNDROME

被引：169

作者：

MAYENO, AN

LIN, F

FOOTE, CS

LOEGERING, DA

AMES, MM

HEDBERG, CW

GLEICH, GJ

机构：

[1] MINNESOTA DEPT HLTH, ACUTE DIS EPIDEMIOL SECT, MINNEAPOLIS, MN 55440 USA

[2] INDIANA UNIV, DEPT CHEM, BLOOMINGTON, IN 47405 USA

[3] UNIV CALIF LOS ANGELES, DEPT CHEM & BIOCHEM, LOS ANGELES, CA 90024 USA

[4] MAYO CLIN & MAYO FDN, DEPT ONCOL, ROCHESTER, MN 55905 USA

来源：

SCIENCE | 1990年 / 250卷 / 4988期

关键词：

D O I：

10.1126/science.2270484

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epidemiologic studies strongly associate eosinophilia-myalgia syndrome (EMS) with ingestion of tryptophan containing a contaminant ("peak E"). Prior reports have suggested that peak E is the di-tryptophan Nα-aminal of acetaldehyde. Spectral and chemical studies now demonstrate that peak E is 1,1′-ethylidenebis[tryptophan]. This novel amino acid may be the etiological agent responsible for EMS, or it may be a marker of a still unidentified causal agent.

引用

页码：1707 / 1708

页数：2

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