SIMILAR EFFECTS OF TREATMENT WITH DESIPRAMINE AND ELECTROCONVULSIVE SHOCK ON 5-HYDROXYTRYPTAMINE-1A RECEPTORS IN RAT-BRAIN

被引:37
作者
PANDEY, SC
ISAAC, L
DAVIS, JM
PANDEY, GN
机构
[1] ILLINOIS STATE PSYCHIAT INST,1601 W TAYLOR ST,CHICAGO,IL 60612
[2] UNIV ILLINOIS,COLL MED,CHICAGO,IL 60612
关键词
5-HT1A RECEPTORS; 8-OH-DPAT (8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN); DESIPRAMINE; ELECTROCONVULSIVE SHOCK; BRAIN (RAT);
D O I
10.1016/0014-2999(91)90297-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of chronic and acute treatment with desipramine (DMI) and electroconvulsive shock (ECS) on 5-hydroxytryptamine1A (5-HT1A) receptors was determined in the cortex and the hippocampus brain regions of rats. We observed that chronic treatment with both DMI and ECS significantly decreased 5-HT1A receptors, as determined by [H-3]8-hydroxy-2-(di-n-propylamino) tetralin ([H-3]8-OH-DPAT) binding, in the cortex but not in the hippocampus. Acute treatment with DMI or ECS did not significantly alter the 5-HT1A receptors in the cortex. Neither chronic nor acute treatment influenced K(D) of [H-3]8-OH-DPAT binding in the cortex or hippocampus. These results thus suggest that in contrast to the effects on 5-HT, receptors, tricyclics as well as ECS produce similar effects on 5-HT1A receptors, suggesting that this site may represent a common site of action for antidepressant treatment.
引用
收藏
页码:221 / 225
页数:5
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