EFFECT OF ALCOHOL AND SMOKING ON PANCREATIC LITHOGENESIS IN THE COURSE OF CHRONIC-PANCREATITIS

被引：82

作者：

CAVALLINI, G ^{[1
]}

TALAMINI, G ^{[1
]}

VAONA, B ^{[1
]}

BOVO, P ^{[1
]}

FILIPPINI, M ^{[1
]}

RIGO, L ^{[1
]}

ANGELINI, G ^{[1
]}

VANTINI, I ^{[1
]}

RIELA, A ^{[1
]}

FRULLONI, L ^{[1
]}

DIFRANCESCO, V ^{[1
]}

BRUNORI, MP ^{[1
]}

BASSI, C ^{[1
]}

PEDERZOLI, P ^{[1
]}

机构：

[1] UNIV VERONA,IST CLIN CHIRURG,I-37100 VERONA,ITALY

来源：

PANCREAS | 1994年 / 9卷 / 01期

关键词：

CHRONIC PANCREATITIS; CIGARETTE SMOKING; PANCREATIC CALCIFICATION;

D O I：

10.1097/00006676-199401000-00006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of the study was to establish whether correlations were discernible between calcification, smoking, and other variables-including alcohol intake-in chronic pancreatitis. A total of 637 patients with chronic pancreatitis diagnosed over the period of 1973-1989 were reviewed. Only patients who had had one or more instrumental tests (ultrasonography, endoscopic retrograde cholangiopancreatography, computed tomography, plain film of the abdomen) every 3 years were included in the study. Onset of calcification was taken as the end point of the follow-up. No statistically significant correlation was found between alcohol intake and calcification. As regards smoking habits, patients were divided into two groups: nonsmokers and medium-to-heavy smokers (greater-than-or-equal-to 10 cigarettes/day). Of 637 patients, only 570 fulfilled our criteria. Three hundred seventy-six patients (66%) developed calcifications, whereas 64 (10%) already presented calcifications at the time of diagnosis. Smoking correlated with formation of calcifications (p < 0.004). The mean time to onset of calcification in smokers was 8 years as against 12 years in nonsmokers. The relative risk of calcification in smokers versus nonsmokers was 1.21 (95% confidence limits: 1.10-1.32). By the end of follow-up (17 years), 277 smokers (69%) with chronic pancreatitis had developed calcifications compared with only 93 nonsmokers (55%). The results show that, in this sample of chronic pancreatitis sufferers, smokers present a significantly increased risk of developing calcifications.

引用

页码：42 / 46

页数：5

共 14 条

[1]

AMMAN RW, 1986, GASTROENTEROLOGY, V95, P1018

[2] IS TOBACCO A RISK FACTOR FOR CHRONIC-PANCREATITIS AND ALCOHOLIC CIRRHOSIS [J].