EXPRESSION OF C-FOS MESSENGER-RNA AFTER A MILD FOCAL CEREBRAL-ISCHEMIA IN SOD-1 TRANSGENIC MICE

被引：35

作者：

KAMII, H

KINOUCHI, H

SHARP, FR

EPSTEIN, CJ

SAGAR, SM

CHAN, PH

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT NEUROSURG,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT NEUROL,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,SAN FRANCISCO,CA 94143

[4] VET AFFAIRS MED CTR,DEPT NEUROL,SAN FRANCISCO,CA 94121

[5] TOHOKU UNIV,SCH MED,INST BRAIN DIS,DIV NEUROSURG,SENDAI,MIYAGI 980,JAPAN

来源：

BRAIN RESEARCH | 1994年 / 662卷 / 1-2期

关键词：

FOCAL BRAIN ISCHEMIA; IMMEDIATE EARLY GENE; C-FOS MESSENGER-RNA; OXYGEN FREE RADICALS; SUPEROXIDE DISMUTASE; TRANSGENIC MOUSE;

D O I：

10.1016/0006-8993(94)90818-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To clarify the role of oxygen free radicals in expression of the c-fos protooncogene, the distribution of c-fos mRNA was investigated in CuZn-superoxide dismutase (SOD-1) transgenic (Tg) mice compared to control nontransgenic (nTg) littermates after a mild (i.e. 10 min) focal cerebral ischemia. c-fos mRNA expression occurred at 1 to 6 h after reperfusion in the ipsilateral hippocampus and thalamus in Tg mice, whereas it did only at 1 h in the same regions in nTg mice. In the ipsilateral cortex, there were no significant differences in the pattern of the expression between nTg and Tg mice. These results suggest that oxygen radicals may suppress the expression of c-fos in the hippocampus and thalamus, the areas known to be without blood supply from the middle cerebral artery, following a mild focal cerebral ischemia and reperfusion.

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页码：240 / 244

页数：5

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