IS DNA-SYNTHESIS A REQUISITE FOR THE DIFFERENTIATION OF LYMPHOCYTES-B INTO IMMUNOGLOBULIN-SECRETING PLASMA-CELLS

被引：12

作者：

ATTALLAH, AM ^{[1
]}

YEATMAN, TJ ^{[1
]}

NOGUCHI, PD ^{[1
]}

PETRICCIANI, JC ^{[1
]}

机构：

[1] US FDA,DIV PATHOL,BETHESDA,MD 20014

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1979年 / 60卷 / 02期

关键词：

D O I：

10.1159/000232334

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A great amount of conflicting evidence has been reported concerning the relationship between DNA synthesis and the differentiation of immunoglobulin-secreting cells. With the development of flow cytometry, it has become possible to analyze lymphocyte populations by making rapid and accurate measurements of cellular DNA content, and by estimating the fraction of cells that synthesize DNA. Application of these techniques to an in vitro culture system stimulated by the T-dcpendent sheep red blood cell antigen has allowed us to investigate cell division in populations of antibody-forming cells. DNA synthesis is apparently not a requisite for the differentiation of immunoglobulin-secreting cells. © 1979 S. Karger AG, Basel.

引用

页码：132 / 139

页数：8

共 28 条

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