IMMUNOLOGICALLY ACTIVE ZONES IN BOVINE GROWTH-HORMONE

被引：13

作者：

FERRARA, P

ZAKIN, MM

PENA, C

PALADINI, AC

机构：

[1] UNIV BUENOS AIRES,FAC FARM,DEPT QUIM BIOL,BUENOS AIRES 1113,ARGENTINA

[2] CTR PARA ESTUDIO HORMONAS HIPOFISARIAS,BUENOS AIRES,ARGENTINA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 12期

关键词：

D O I：

10.1002/eji.1830091219

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigenic determinant areas were detected in bovine growth hormone fragments 6–124 and 125–149, the former being predominant. Reduction and carboxymethylation of disulfide bridge 53–164 destroys the immunological reactivity of the area which is little affected by reduction and carbamoylmethylation. All the activity found in fragment 6–124 seems to be concentrated in the sequence 87–124. Copyright © 1979 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：1020 / 1023

页数：4

共 8 条

[1]

CRESTFIELD AM, 1963, J BIOL CHEM, V238, P622

[2] ADDITION [J].