AN EFFECTIVE CHELATING AGENT FOR LABELING OF MONOCLONAL-ANTIBODY WITH BI-212 FOR ALPHA-PARTICLE MEDIATED RADIOIMMUNOTHERAPY

被引：57

作者：

BRECHBIEL, MW

PIPPIN, CG

MCMURRY, TJ

MILENIC, D

ROSELLI, M

COLCHER, D

GANSOW, OA

机构：

[1] NCI,RADIAT ONCOL BRANCH,INORGAN & RADIOIMMUNE CHEM SECT,BETHESDA,MD 20892

[2] NCI,TUMOR IMMUNOL & BIOL LAB,BETHESDA,MD 20892

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 17期

关键词：

D O I：

10.1039/c39910001169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ligand N[2-amino-3-(p-isothiocyanatophenyl)propyl]-(+/-)-trans-1,2-diaminocyclohexane-N,N',N''-pentaacetic acid has been synthesized and linked to IgG and to monoclonal antibody B72.3, and labelled with Bi-206 and Bi-212 to demonstrate the in vivo stability of the label and its utility for Bi-212-radioimmunotherapy.

引用

页码：1169 / 1170

页数：2

共 16 条

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