N-FORMYLATION OF AN AROMATIC AMINE AS A METABOLIC PATHWAY

被引：21

作者：

GOTHOSKAR, SV ^{[1
]}

BENJAMIN, T ^{[1
]}

ROLLER, PP ^{[1
]}

WEISBURGER, EK ^{[1
]}

机构：

[1] NCI,CARCINOGEN METAB LAB,BETHESDA,MD 20205

来源：

XENOBIOTICA | 1979年 / 9卷 / 09期

关键词：

D O I：

10.3109/00498257909042318

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephro-toxicity in females, caused by deposits of crystalline material in the kidney tubules. 2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of urine of rats fed 2-AAQ. 3. This represents the first case of identification of the N-formyl derivative of a primary aromatic amine as a metabolite in vivo. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：533 / 537

页数：5

共 9 条

[1]

BAKER JR, 1975, J TOXICOL ENV HEALTH, V1, P1

[2] BIOCHEMISTRY OF AROMATIC AMINES - 2-FORMAMIDO-1-NAPHTHYL HYDROGEN SULPHATE A METABOLITE OF 2-NAPHTHYLAMINE [J].