EFFECTS OF SCIATIC-NERVE TRANSPLANTS AFTER FIMBRIA-FORNIX LESION - EXAMINATION OF THE ROLE OF NERVE GROWTH-FACTOR

被引：23

作者：

MESSERSMITH, DJ

FABRAZZO, M

MOCCHETTI, I

KROMER, LF

机构：

[1] GEORGETOWN UNIV,SCH MED,DEPT ANAT & CELL BIOL,3900 RESERVOIR RD NW,WASHINGTON,DC 20007

[2] GEORGETOWN UNIV,SCH MED,FIDIA GEORGETOWN INST NEUROSCI,WASHINGTON,DC 20007

来源：

BRAIN RESEARCH | 1991年 / 557卷 / 1-2期

关键词：

SEPTUM; HIPPOCAMPUS; CHOLINERGIC; SEPTOHIPPOCAMPAL PATHWAY; 2-SITE ENZYME IMMUNOASSAY; ACETYLCHOLINESTERASE HISTOCHEMISTRY;

D O I：

10.1016/0006-8993(91)90147-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater than in animals with lesions only. These results suggest a role for NGF in the ingrowth of axons into the transplants and in the increase in ChAT(+) septal neurons previously observed at this post-transplant time.

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收藏

页码：293 / 297

页数：5

相关论文

共 28 条

[1] REASSESSING THE CHOLINERGIC BASAL FOREBRAIN - NOMENCLATURE SCHEMATA AND CONCEPTS [J].

BUTCHER, LL ;

SEMBA, K .

TRENDS IN NEUROSCIENCES, 1989, 12 (12) :483-485

[2]

FABRAZZO M, 1991, MOL PHARMACOL, V39, P144

[3] TIME COURSE OF THE ELEVATION OF NERVE GROWTH-FACTOR (NGF) CONTENT IN THE HIPPOCAMPUS AND SEPTUM FOLLOWING LESIONS OF THE SEPTOHIPPOCAMPAL PATHWAY IN RATS [J].

GASSER, UE ;

WESKAMP, G ;

OTTEN, U ;

DRAVID, AR .

BRAIN RESEARCH, 1986, 376 (02) :351-356

[4] NERVE GROWTH-FACTOR (NGF) REVERSES AXOTOMY-INDUCED DECREASES IN CHOLINE-ACETYLTRANSFERASE, NGF RECEPTOR AND SIZE OF MEDIAL SEPTUM CHOLINERGIC NEURONS [J].

HAGG, T ;

FASSHOLMES, B ;

VAHLSING, HL ;

MANTHORPE, M ;

CONNER, JM ;

VARON, S .

BRAIN RESEARCH, 1989, 505 (01) :29-38

[5] SEPTOHIPPOCAMPAL CHOLINERGIC AXONAL REGENERATION THROUGH PERIPHERAL-NERVE BRIDGES - QUANTIFICATION AND TEMPORAL DEVELOPMENT [J].

HAGG, T ;

VAHLSING, HL ;

MANTHORPE, M ;

VARON, S .

EXPERIMENTAL NEUROLOGY, 1990, 109 (02) :153-163

[6] DELAYED TREATMENT WITH NERVE GROWTH-FACTOR REVERSES THE APPARENT LOSS OF CHOLINERGIC NEURONS AFTER ACUTE BRAIN-DAMAGE [J].

HAGG, T ;

MANTHORPE, M ;

VAHLSING, HL ;

VARON, S .

EXPERIMENTAL NEUROLOGY, 1988, 101 (02) :303-312

[7]

HEFTI F, 1986, J NEUROSCI, V6, P2155

[8] CHANGES OF NERVE GROWTH-FACTOR SYNTHESIS IN NONNEURONAL CELLS IN RESPONSE TO SCIATIC-NERVE TRANSECTION [J].

HEUMANN, R ;

KORSCHING, S ;

BANDTLOW, C ;

THOENEN, H .

JOURNAL OF CELL BIOLOGY, 1987, 104 (06) :1623-1631

[9] EXPRESSION AND POSSIBLE FUNCTION OF NERVE GROWTH-FACTOR RECEPTORS ON SCHWANN-CELLS [J].

JOHNSON, EM ;

TANIUCHI, M ;

DISTEFANO, PS .

TRENDS IN NEUROSCIENCES, 1988, 11 (07) :299-304

[10] CHOLINERGIC DENERVATION OF THE RAT HIPPOCAMPUS BY FIMBRIAL TRANSECTION LEADS TO A TRANSIENT ACCUMULATION OF NERVE GROWTH-FACTOR (NGF) WITHOUT CHANGE IN MESSENGER RNANGF CONTENT [J].

KORSCHING, S ;

HEUMANN, R ;

THOENEN, H ;

HEFTI, F .

NEUROSCIENCE LETTERS, 1986, 66 (02) :175-180