IDENTIFICATION OF HIV-1 IN SEMEN FOLLOWING PRIMARY HIV-1 INFECTION

被引:59
作者
TINDALL, B [1 ]
EVANS, L [1 ]
CUNNINGHAM, P [1 ]
MCQUEEN, P [1 ]
HURREN, L [1 ]
VASAK, E [1 ]
MOONEY, J [1 ]
COOPER, DA [1 ]
机构
[1] ST VINCENTS HOSP,CTR IMMUNOL,SYDNEY,NSW 2010,AUSTRALIA
关键词
HIV-1; SEMEN; TRANSMISSION;
D O I
10.1097/00002030-199209000-00006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To determine whether HIV could be identified in semen samples during the first few weeks after infection. Design: A series of three homosexual men with symptomatic primary HIV-1 infection. Methods: Each subject provided a series of semen samples that was examined for HIV-1 by virus culture, polymerase chain reaction (PCR) and transmission electron micrography. Results: The first samples obtained for each subject (17, 22 and 24 days following onset of primary HIV-1 infection) were all positive by PCR and negative by viral culture. Of 13 samples obtained during the first 80 days after onset of primary HIV-1 infection and analysed by PCR, 10 were positive. Only one of these samples was virus culture-positive. Four semen samples obtained from two subjects during treatment with zidovudine were PCR-positive. Eight samples were examined for presence of HIV-1 by electron microscopy and one was found to be positive. Conclusions: These results indicate that men with HIV-1 infection are potentially infectious through sexual transmission during the first few weeks after infection. The findings emphasize that individuals in all stages of HIV-1 infection should practise safer sex to reduce transmission of HIV-1.
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页码:949 / 952
页数:4
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