MIXED ACETOXY-BENZOXY TAXANE ESTERS FROM TAXUS-BREVIFOLIA

被引:25
作者
CHU, A
ZAJICEK, J
DAVIN, LB
LEWIS, NG
CROTEAU, RB
机构
[1] WASHINGTON STATE UNIV,INST BIOL CHEM,467 CLARK HALL,PULLMAN,WA 99163
[2] WASHINGTON STATE UNIV,CTR NMR SPECT,PULLMAN,WA 99163
基金
美国国家卫生研究院;
关键词
TAXUS-BREVIFOLIA; TAXACEAE; YEW; BARK; DITERPENOIDS; TAXOL; TAXANES; BACCATIN-VL;
D O I
10.1016/0031-9422(92)80453-L
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Three new taxane derivatives were isolated from the bark of Taxus brevifolia and their structures established as 5beta,20-epoxy-1beta-hydroxy-4alpha-7beta,13alpha-triacetoxy-2alpha,9alpha,10beta-tribenzoxy-tax-11-ene, 2alpha,10beta-dibenzoxy-5beta,20-epoxy-1beta-hydroxy-4alpha,7beta,9alpha,13alpha-tetraacetoxy-tax-11-ene and 2alpha,7beta-dibenzoxy-5beta,20-epoxy-1beta-hydroxy-4alpha,9alpha,10beta,13alpha-tetraacetoxy-tax-11-ene.
引用
收藏
页码:4249 / 4252
页数:4
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