SUBCHRONIC TOXICITY STUDIES OF SALATRIM STRUCTURED TRIACYLGLYCEROLS IN RATS .3. TRIACYLGLYCEROLS COMPOSED OF STEARATE, ACETATE, PROPIONATE, AND BUTYRATE

SALATRIM 234CS lot A018 and SALATRIM 234CA lot A019 are structured triacylglycerols having lower caloric availability (4.5-6.0 kcal/g) than corn oil (9.0 kcal/g). Rats were fed both SALATRIM fats at 2 %, 5 % and 10 % or corn oil at 10 % in the diet for 13 weeks. Body weight and feed consumption varied predictably with caloric density of the diets. Ophthalmologic observations, serum and liver concentrations of fat-soluble vitamins, clinical pathology, organ weights, and necropsy findings were unaffected by treatment. Small variations in bone mineral concentrations of 10 % SALATRIM and corn oil rats were considered to be related to the levels of unsaturated fatty acids in these diets. A slightly increased incidence of renal mineralization was noted in mid- and high-dose SALATRIM 234CA lot A019 and SALATRIM 234CS lot A018 females. This finding was considered to be possibly related to a general mineral effect indicated by the changes in bone minerals. Overall, neither SALATRIM fat produced biologically significant effects.