PULMONARY O-2 TOXICITY - ROLE OF ENDOGENOUS TUMOR-NECROSIS-FACTOR

被引：31

作者：

TSAN, MF

WHITE, JE

MICHELSEN, PB

WONG, GHW

机构：

[1] ALBANY MED COLL,DEPT MED,ALBANY,NY

[2] ALBANY MED COLL,DEPT PHYSIOL & CELL BIOL,ALBANY,NY

[3] GENENTECH INC,DEPT MOLEC BIOL,S SAN FRANCISCO,CA 94080

来源：

EXPERIMENTAL LUNG RESEARCH | 1995年 / 21卷 / 04期

关键词：

TNF; O-2; TOXICITY;

D O I：

10.3109/01902149509031761

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The role of endogenous tumor necrosis factor (TNF) in the pathogenesis of pulmonary O-2 toxicity was investigated. Intratracheal insufflation of anti-TNF antibodies prolonged the survival of rats exposed to 100% O-2. No TNF bioactivity or immunoreactive protein was detectable in the alveolar lavage fluid or lung homogenate of rats exposed to normoxia or hyperoxia. However, levels of pulmonary TNF mRNA were markedly enhanced in rats exposed to hyperoxia. These results suggest that hyperoxia may cause the production of low level TNF, which in turn enhances O-2 toxicity.

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页码：589 / 597

页数：9

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