LONG-TERM COMPLETE URETERAL OBSTRUCTION IN THE YOUNG-RAT

被引：16

作者：

JOSEPHSON, S

HEMSEN, A

机构：

[1] Department of Paediatric Surgery, St. Göran’s Children’s Hospital, Stockholm

[2] Department of Physiology and Pharmacology, Karolinska Institute, Stockholm

来源：

UROLOGIA INTERNATIONALIS | 1994年 / 53卷 / 02期

关键词：

URETERAL OBSTRUCTION; RENAL ENDOTHELIN; WEANLING RATS;

D O I：

10.1159/000282636

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Complete obstruction of one ureter was created in 3-week-old weanling rats. The endothelin concentration in the renal tissue was measured by radioimmunoassay. In the obstructed kidney, a substantial increase was observed, after 1 week +90%, after 2 weeks +55%, and after 4 weeks +145% compared to the control rat kidneys. The endothelin-l /endothelin-3 ratio was found to be considerably raised, indicating a predominance of the vasoconstrictor effects of the - with reference to vasoactivity - bi-potential endothelin. Its contribution to vasoconstriction and to glomerular destruction in obstructive nephropathy is discussed.

引用

页码：57 / 61

页数：5

共 24 条

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