ENHANCED CELL-DIFFERENTIATION WHEN RB IS HYPOPHOSPHORYLATED AND DOWN-REGULATED BY RADICICOL, A SRC-KINASE INHIBITOR

被引：19

作者：

YEN, A ^{[1
]}

SOONG, S ^{[1
]}

KWON, HJ ^{[1
]}

YOSHIDA, M ^{[1
]}

BEPPU, T ^{[1
]}

VARVAYANIS, S ^{[1
]}

机构：

[1] UNIV TOKYO, FAC AGR, DEPT AGR CHEM, TOKYO 113, JAPAN

来源：

EXPERIMENTAL CELL RESEARCH | 1994年 / 214卷 / 01期

关键词：

D O I：

10.1006/excr.1994.1245

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radicicol, an inhibitor of src or are-like kinases, causes hypophosphorylation and down-regulation of the RB retinoblastoma tumor suppressor protein in HL-60 human promyelocytic leukemia cells. Both of these changes in the RB protein typically are associated with myeloid or monocytic differentiation of these cells induced by retinoic acid or 1,25-dihydroxy vitamin D3. When added with either inducer, radicicol caused the typically induced myeloid or monocytic differentiation of these cells to be accelerated. By itself radicicol caused a transient inhibition of G1 to S transit, but did not cause phenotypic conversion. The down-regulation and dephosphorylation of RB by radicicol may thus facilitate cell differentiation. (C) 1994 Academic Press, Inc.

引用

页码：163 / 171

页数：9

共 31 条

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[2]

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