SERUM ZINC, SENILE PLAQUES, AND NEUROFIBRILLARY TANGLES - FINDINGS FROM THE NUN STUDY

被引:39
作者
TULLY, CL
SNOWDON, DA
MARKESBERY, WR
机构
[1] UNIV KENTUCKY, COLL MED, SANDERS BROWN CTR AGING, DEPT PREVENT MED, LEXINGTON, KY 40506 USA
[2] UNIV KENTUCKY, COLL MED, SANDERS BROWN CTR AGING, DEPT NEUROL & PATHOL, LEXINGTON, KY 40506 USA
[3] VET ADM MED CTR, LEXINGTON, KY 40511 USA
关键词
ZINC; TRACE ELEMENTS; SENILE PLAQUES; NEUROFIBRILLARY TANGLES; AGED; ALZHEIMERS DISEASE; DEMENTIA;
D O I
10.1097/00001756-199511000-00002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
ZINC appears to have a role in binding amyloid precursor protein in vitro, but it is not known whether zinc plays a role in senile plaque formation in vivo in humans. Serum zinc concentrations were available from 12 sisters who died in the Nun Study, a longitudinal study of aging and Alzheimer's disease. Fasting serum zinc concentrations, determined approximately 1 year before death, showed moderate to strong negative correlations with senile prague counts in seven brain regions. In all brain regions combined, the age-adjusted negative correlations with serum zinc were statistically significant for total senile plaques and diffuse plaques, and suggestive for neuritic plaques. Thus serum zinc in the normal range may be associated with low senile plaque counts in the elderly.
引用
收藏
页码:2105 / 2108
页数:4
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