DIETARY CALCIUM SUPPLEMENTATION RESTORES PRESSURE NATRIURESIS RESPONSES IN DAHL-S RATS

被引：7

作者：

BUTLER, TV ^{[1
]}

CAMERON, J ^{[1
]}

KIRCHNER, KA ^{[1
]}

机构：

[1] DEPT VET AFFAIRS MED CTR,MED SERV 111,JACKSON,MS 39216

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1995年 / 8卷 / 06期

关键词：

DIET; CALCIUM; DAHL RAT; PRESSURE NATRIURESIS; SALT-SENSITIVE HYPERTENSION;

D O I：

10.1016/0895-7061(95)00034-M

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Calcium supplementation prevents hypertension in Dahl S (DS) rats. Because abnormal pressure natriuresis may contribute to the development of hypertension, we examined the effect of calcium on pressure natriuresis. DS and Dahl R (DR) rats maintained on a 4% sodium diet containing either 0.5% or 2% calcium for 4 weeks were anesthetized; sodium excretion, renal blood flow, and inulin clearance were determined at perfusion pressures of 100, 125, and 156 mm Hg. Inulin clearance and renal blood flow were not different between groups. Sodium excretion increased with increasing renal perfusion pressure in all groups. The slope of the line relating renal perfusion pressure to sodium excretion was greater (P < .05) in DR rats than in DS rats on normal calcium intakes. High calcium intake normalized the slope of the line relating renal perfusion pressure to sodium excretion in DS rats, but had no effect on DR rats. Thus, dietary calcium supplementation normalizes the blunted pressure natriuresis response in the DS rat and may contribute to the prevention of hypertension.

引用

页码：615 / 621

页数：7

共 42 条

[1]

Resnick L.M., Uniformity and diversity of calcium metabolism in hypertension: A conceptual framework, Am J Med, 82, pp. 16-25, (1987)

[2]

McCarron P.A., Morris C.D., Blood pressure response to oral calcium in persons with mild to moderate hypertension, Ann Intern Med, 103, pp. 825-831, (1985)

[3]

Zemel M.B., Gualdoni S.M., Walsh M.F., Et al., Effect of sodium and calcium on calcium metabolism and blood pressure regulation in hypertensive black adults, J Hypertens, 4, pp. S364-S366, (1986)

[4]

Ayachi S., Increased dietary calcium lowers blood pressure in the spontaneously hypertensive rat, Metabolism, 28, pp. 1234-1238, (1979)

[5]

Kageyama Y., Bravo E.L., Neurohumoral and hemodynamic responses to dietary calcium supplementation in deoxycorticosterone-salt hypertensive dogs, Hypertension, 9, pp. III166-III170, (1987)

[6]

Kageyama Y., Suzuki H., Arima K., Saruta T., Oral calcium treatment lowers blood pressure in renovascular hypertensive rats by suppressing the renin angiotensin system, Hypertension, 10, pp. 375-382, (1987)

[7]

McCarron D.A., Lucas P.A., Shneidman R.J., Et al., Blood pressure development of the spontaneously hypertensive rat after concurrent manipulations of dietary Ca<sup>2+</sup> and Na<sup>+</sup>, J Clin Invest, 76, pp. 1147-1154, (1985)

[8]

Peuler J.D., Morgan A.A., Mark A.L., High calcium diet reduces blood pressure in Dahl salt-sensitive rats by neural mechanisms, Hypertension, 9, pp. III159-III165, (1987)

[9]

Grobbee D.E., Hoffman A., Effect of calcium supplementation on diastolic blood pressure in young people with mild hypertension, Lancet, 2, pp. 703-707, (1986)

[10]

Roman R.J., Abnormal renal hemodynamics and pressure natriuresis relationship in Dahl salt-sensitive rats, Am J Physiol, 251, pp. F57-F65, (1986)

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