Long non-coding RNAs in stem cells and cancer

被引：151

作者：

Eades, Gabriel ^{[1
]}

Zhang, Yong-Shu ^{[1
]}

Li, Qing-Lin ^{[1
]}

Xia, Ji-Xiang ^{[1
]}

Yao, Yuan ^{[1
]}

Zhou, Qun ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Dept Biochem & Mol Biol, 685 W Baltimore St 480, Baltimore, MD 21201 USA

来源：

WORLD JOURNAL OF CLINICAL ONCOLOGY | 2014年 / 5卷 / 02期

关键词：

Long non-coding RNA; Stem cell; Cancer stem cell;

D O I：

10.5306/wjco.v5.i2.134

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

An overwhelming majority of the transcribed genome encodes for non-coding RNA (ncRNA) sequences. Deep sequencing of the transcriptome has uncovered tens of thousands of long ncRNA (lncRNA) sequences. However, little is known regarding the possible functions for a vast majority of these sequences. Among those lncRNAs whose function has been experimentally validated, most serve as regulators of gene expression. LncRNAs have been found to be critical to development and homeostasis and they have been implicated in several pathologies including cancer. Here, we examine the functions and underlying mechanisms of lncRNAs in stem cells and in cancer biology, areas linked by the actions of lncRNAs. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

引用

页码：134 / 141

页数：8

共 58 条

[1]

The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10 [J].

Bochenek, Gregor ;

Haesler, Robert ;

El Mokhtari, Nour-Eddine ;

Koenig, Inke R. ;

Loos, Bruno G. ;

Jepsen, Soeren ;

Rosenstiel, Philip ;

Schreiber, Stefan ;

Schaefer, Arne S. .

HUMAN MOLECULAR GENETICS, 2013, 22 (22) :4516-4527

[2]

Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma [J].

Braconi, Chiara ;

Valeri, Nicola ;

Kogure, Takayuki ;

Gasparini, Pierluigi ;

Huang, Nianyuan ;

Nuovo, Gerard J. ;

Terracciano, Luigi ;

Croce, Carlo M. ;

Patel, Tushar .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (02) :786-791

[3]

A GENE FROM THE REGION OF THE HUMAN X-INACTIVATION CENTER IS EXPRESSED EXCLUSIVELY FROM THE INACTIVE X-CHROMOSOME [J].

BROWN, CJ ;

BALLABIO, A ;

RUPERT, JL ;

LAFRENIERE, RG ;

GROMPE, M ;

TONLORENZI, R ;

WILLARD, HF .

NATURE, 1991, 349 (6304) :38-44

[4]

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes [J].

Carpenter, Susan ;

Aiello, Daniel ;

Atianand, Maninjay K. ;

Ricci, Emiliano P. ;

Gandhi, Pallavi ;

Hall, Lisa L. ;

Byron, Meg ;

Monks, Brian ;

Henry-Bezy, Meabh ;

Lawrence, Jeanne B. ;

O'Neill, Luke A. J. ;

Moore, Melissa J. ;

Caffrey, Daniel R. ;

Fitzgerald, Katherine A. .

SCIENCE, 2013, 341 (6147) :789-792

[5]

Finishing the euchromatic sequence of the human genome [J].

Collins, FS ;

Lander, ES ;

Rogers, J ;

Waterston, RH .

NATURE, 2004, 431 (7011) :931-945

[6]

An integrated encyclopedia of DNA elements in the human genome [J].

Dunham, Ian ;

Kundaje, Anshul ;

Aldred, Shelley F. ;

Collins, Patrick J. ;

Davis, CarrieA. ;

Doyle, Francis ;

Epstein, Charles B. ;

Frietze, Seth ;

Harrow, Jennifer ;

Kaul, Rajinder ;

Khatun, Jainab ;

Lajoie, Bryan R. ;

Landt, Stephen G. ;

Lee, Bum-Kyu ;

Pauli, Florencia ;

Rosenbloom, Kate R. ;

Sabo, Peter ;

Safi, Alexias ;

Sanyal, Amartya ;

Shoresh, Noam ;

Simon, Jeremy M. ;

Song, Lingyun ;

Trinklein, Nathan D. ;

Altshuler, Robert C. ;

Birney, Ewan ;

Brown, James B. ;

Cheng, Chao ;

Djebali, Sarah ;

Dong, Xianjun ;

Dunham, Ian ;

Ernst, Jason ;

Furey, Terrence S. ;

Gerstein, Mark ;

Giardine, Belinda ;

Greven, Melissa ;

Hardison, Ross C. ;

Harris, Robert S. ;

Herrero, Javier ;

Hoffman, Michael M. ;

Iyer, Sowmya ;

Kellis, Manolis ;

Khatun, Jainab ;

Kheradpour, Pouya ;

Kundaje, Anshul ;

Lassmann, Timo ;

Li, Qunhua ;

Lin, Xinying ;

Marinov, Georgi K. ;

Merkel, Angelika ;

Mortazavi, Ali .

NATURE, 2012, 489 (7414) :57-74

[7]

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome [J].

Engreitz, Jesse M. ;

Pandya-Jones, Amy ;

McDonel, Patrick ;

Shishkin, Alexander ;

Sirokman, Klara ;

Surka, Christine ;

Kadri, Sabah ;

Xing, Jeffrey ;

Goren, Alon ;

Lander, Eric S. ;

Plath, Kathrin ;

Guttman, Mitchell .

SCIENCE, 2013, 341 (6147) :767-+

[8]

HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts [J].

Ferdin, J. ;

Nishida, N. ;

Wu, X. ;

Nicoloso, M. S. ;

Shah, M. Y. ;

Devlin, C. ;

Ling, H. ;

Shimizu, M. ;

Kumar, K. ;

Cortez, M. A. ;

Ferracin, M. ;

Bi, Y. ;

Yang, D. ;

Czerniak, B. ;

Zhang, W. ;

Schmittgen, T. D. ;

Voorhoeve, M. P. ;

Reginato, M. J. ;

Negrini, M. ;

Davuluri, R. V. ;

Kunej, T. ;

Ivan, M. ;

Calin, G. A. .

CELL DEATH AND DIFFERENTIATION, 2013, 20 (12) :1675-1687

[9]

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity [J].

Friedl, Peter ;

Alexander, Stephanie .

CELL, 2011, 147 (05) :992-1009

[10]

The NeST Long ncRNA Controls Microbial Susceptibility and Epigenetic Activation of the Interferon-γ Locus [J].

Gomez, J. Antonio ;

Wapinski, Orly L. ;

Yang, Yul W. ;

Bureau, Jean-Francois ;

Gopinath, Smita ;

Monack, Denise M. ;

Chang, Howard Y. ;

Brahic, Michel ;

Kirkegaard, Karla .

CELL, 2013, 152 (04) :743-754

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