EFFECTS OF CIGUATOXIN ON NERVE EXCITABILITY IN RATS .1.

被引：38

作者：

CAMERON, J

FLOWERS, AE

CAPRA, MF

机构：

[1] QUEENSLAND UNIV TECHNOL,DEPT PUBL HLTH & NUTR,GEORGE ST,BRISBANE 4000,AUSTRALIA

[2] PRINCESS ALEXANDRA HOSP,DEPT NEUROL,BRISBANE,AUSTRALIA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1991年 / 101卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

CIGUATERA POISONING; VENTRAL NERVE RAT TAIL; NERVE CONDUCTION VELOCITY; F-WAVES; REFRACTORY PERIODS; SUPERNORMAL PERIOD; SODIUM CHANNELS;

D O I：

10.1016/0022-510X(91)90021-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ciguatera poisoning is the most common fish food poisoning encountered in man. Electrophysiological studies were performed on the ventral nerve of the tail on adult rats following intraperitoneal injection of toxic fish extract. Significant slowing of both mixed and motor nerve conduction velocities and F wave responses were recorded. Motor and mixed nerve amplitudes were significantly reduced. Both absolute and supernormal periods were significantly prolonged together with an exaggeration of the supernormal response. These findings indirectly suggest that ciguatoxin acts on mammalian nerve by prolonging sodium channel activation.

引用

页码：87 / 92

页数：6

共 31 条

[1] CLINICAL OBSERVATIONS ON 3009 CASES OF CIGUATERA (FISH POISONING) IN THE SOUTH-PACIFIC [J].