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INHIBITION OF SYMPATHETIC TRANSMISSION IN RAT-HEART BY CLONIDINE - ROLES OF STIMULATION FREQUENCY, ENDOGENOUS FEEDBACK AND NORADRENALINE RE-UPTAKE
被引:25
作者
:
DOCHERTY, JR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GLASGOW,INST PHYSIOL,GLASGOW G12 8QQ,SCOTLAND
UNIV GLASGOW,INST PHYSIOL,GLASGOW G12 8QQ,SCOTLAND
DOCHERTY, JR
[
1
]
MCGRATH, JC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV GLASGOW,INST PHYSIOL,GLASGOW G12 8QQ,SCOTLAND
UNIV GLASGOW,INST PHYSIOL,GLASGOW G12 8QQ,SCOTLAND
MCGRATH, JC
[
1
]
机构
:
[1]
UNIV GLASGOW,INST PHYSIOL,GLASGOW G12 8QQ,SCOTLAND
来源
:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
|
1979年
/ 309卷
/ 03期
关键词
:
Alpha adrenoceptor agonists;
Clonidine;
Heart;
drug effects;
Pre-synaptic alpha-adrenoceptors;
Sympathetic nervous system;
D O I
:
10.1007/BF00504754
中图分类号
:
R9 [药学];
学科分类号
:
1007 ;
摘要
:
The inhibitory effects of clonidine were compared with other procedures which reduce the effector response to sympathetic cardioaccelerator nerve stimulation in the pithed rat. The effect of clonidine was most marked against responses to stimulation with relatively short trains of pulses and/or low frequencies of stimulation but a similar effect could be achieved by stimulating fewer fibres, by pretreating the rats with reserpine or by acute administration of guanethidine or propranolol. Unlike the other procedures, however, clonidine did not abolish responses. The effects of clonidine were similar whether or not endogenous α-adrenoceptor-mediated feedback could be demonstrated. After blockade with cocaine of the neuronal re-uptake of transmitter noradrenaline, the inhibitory effect of clonidine was undiminished when the effect of cocaine on the frequency/response curve was taken into account. It is concluded that with frequencies and train lengths within the physiological range relative resistance to the inhibitory effect of clonidine is more dependent on post-junctional summation than on the development of pre-junctional facilitation or feedback mechanisms. Even with a single stimulus, however, the inhibitory effect of clonidine was limited suggesting that a portion of transmitter release is inaccessible to such blockade. © 1979 Springer-Verlag.
引用
收藏
页码:225 / 233
页数:9
相关论文
共 25 条
[1]
POSSIBLE ROLE OF A BETA-ADRENOCEPTOR IN REGULATION OF NORADRENALINE RELEASE BY NERVE-STIMULATION THROUGH A POSITIVE FEEDBACK MECHANISM
ADLERGRASCHINSK.E
论文数:
0
引用数:
0
h-index:
0
机构:
CONSEJO NACL INVEST CIENT & TECNICAS, INST INVEST FARMACOL, JUNIN 956-5 PISO, BUENOS AIRES, ARGENTINA
CONSEJO NACL INVEST CIENT & TECNICAS, INST INVEST FARMACOL, JUNIN 956-5 PISO, BUENOS AIRES, ARGENTINA
ADLERGRASCHINSK.E
LANGER, SZ
论文数:
0
引用数:
0
h-index:
0
机构:
CONSEJO NACL INVEST CIENT & TECNICAS, INST INVEST FARMACOL, JUNIN 956-5 PISO, BUENOS AIRES, ARGENTINA
CONSEJO NACL INVEST CIENT & TECNICAS, INST INVEST FARMACOL, JUNIN 956-5 PISO, BUENOS AIRES, ARGENTINA
LANGER, SZ
[J].
BRITISH JOURNAL OF PHARMACOLOGY,
1975,
53
(01)
: 43
-
50
[2]
EFFECTS OF CLONIDINE AND GUANETHIDINE ON PERIPHERAL SYMPATHETIC-NERVE FUNCTION IN PITHED RAT
ARMSTRON.JM
论文数:
0
引用数:
0
h-index:
0
机构:
WELLCOME RES LABS,PHARMACOL LAB,BECKENHAM BR3 3BS,KENT,ENGLAND
WELLCOME RES LABS,PHARMACOL LAB,BECKENHAM BR3 3BS,KENT,ENGLAND
ARMSTRON.JM
BOURA, ALA
论文数:
0
引用数:
0
h-index:
0
机构:
WELLCOME RES LABS,PHARMACOL LAB,BECKENHAM BR3 3BS,KENT,ENGLAND
WELLCOME RES LABS,PHARMACOL LAB,BECKENHAM BR3 3BS,KENT,ENGLAND
BOURA, ALA
[J].
BRITISH JOURNAL OF PHARMACOLOGY,
1973,
47
(04)
: 850
-
852
[3]
DOCHERTY JP, UNPUBLISHED
[4]
SYMPATHOMIMETIC EFFECTS OF PANCURONIUM-BROMIDE ON CARDIOVASCULAR-SYSTEM OF PITHED RAT - COMPARISON WITH EFFECTS OF DRUGS BLOCKING NEURONAL UPTAKE OF NORADRENALINE
DOCHERTY, JR
论文数:
0
引用数:
0
h-index:
0
DOCHERTY, JR
MCGRATH, JC
论文数:
0
引用数:
0
h-index:
0
MCGRATH, JC
[J].
BRITISH JOURNAL OF PHARMACOLOGY,
1978,
64
(04)
: 589
-
599
[5]
DOCHERTY JR, 1977, J PHYSIOL-LONDON, V273, pP63
[6]
DOCHERTY JR, 1977, BRIT J PHARMACOL, V61, pP472
[7]
DOCHERTY JR, 1978, BRIT J PHARMACOL, V64, pP419
[8]
AN ANALYSIS OF SOME FACTORS INFLUENCING ALPHA-ADRENOCEPTOR FEEDBACK AT THE SYMPATHETIC JUNCTION IN THE RAT-HEART
DOCHERTY, JR
论文数:
0
引用数:
0
h-index:
0
机构:
Institute of Physiology, University of Glasgow, Glasgow
DOCHERTY, JR
MCGRATH, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Institute of Physiology, University of Glasgow, Glasgow
MCGRATH, JC
[J].
BRITISH JOURNAL OF PHARMACOLOGY,
1979,
66
(01)
: 55
-
63
[9]
EFFECT OF CLONIDINE ON CARDIAC ACCELERATION IN PITHED RATS
DOXEY, JC
论文数:
0
引用数:
0
h-index:
0
机构:
RECKITT & COLMAN LTD,DIV PHARMACEUT,HULL HU8 7DS,ENGLAND
RECKITT & COLMAN LTD,DIV PHARMACEUT,HULL HU8 7DS,ENGLAND
DOXEY, JC
[J].
JOURNAL OF PHARMACY AND PHARMACOLOGY,
1977,
29
(03)
: 173
-
174
[10]
EFFECTS OF ALPHA-ADRENOCEPTOR AGONISTS AND ANTAGONISTS ON PRE-SYNAPTICALLY AND POSTSYNAPTICALLY LOCATED ALPHA-ADRENOCEPTORS
DREW, GM
论文数:
0
引用数:
0
h-index:
0
机构:
ALLEN & HANBURYS RES LTD,DEPT PHARMACOL,WARE SG1I ODJ,HERTFORDSHIRE,ENGLAND
ALLEN & HANBURYS RES LTD,DEPT PHARMACOL,WARE SG1I ODJ,HERTFORDSHIRE,ENGLAND
DREW, GM
[J].
EUROPEAN JOURNAL OF PHARMACOLOGY,
1976,
36
(02)
: 313
-
320
←
1
2
3
→
共 25 条
[1]
POSSIBLE ROLE OF A BETA-ADRENOCEPTOR IN REGULATION OF NORADRENALINE RELEASE BY NERVE-STIMULATION THROUGH A POSITIVE FEEDBACK MECHANISM
ADLERGRASCHINSK.E
论文数:
0
引用数:
0
h-index:
0
机构:
CONSEJO NACL INVEST CIENT & TECNICAS, INST INVEST FARMACOL, JUNIN 956-5 PISO, BUENOS AIRES, ARGENTINA
CONSEJO NACL INVEST CIENT & TECNICAS, INST INVEST FARMACOL, JUNIN 956-5 PISO, BUENOS AIRES, ARGENTINA
ADLERGRASCHINSK.E
LANGER, SZ
论文数:
0
引用数:
0
h-index:
0
机构:
CONSEJO NACL INVEST CIENT & TECNICAS, INST INVEST FARMACOL, JUNIN 956-5 PISO, BUENOS AIRES, ARGENTINA
CONSEJO NACL INVEST CIENT & TECNICAS, INST INVEST FARMACOL, JUNIN 956-5 PISO, BUENOS AIRES, ARGENTINA
LANGER, SZ
[J].
BRITISH JOURNAL OF PHARMACOLOGY,
1975,
53
(01)
: 43
-
50
[2]
EFFECTS OF CLONIDINE AND GUANETHIDINE ON PERIPHERAL SYMPATHETIC-NERVE FUNCTION IN PITHED RAT
ARMSTRON.JM
论文数:
0
引用数:
0
h-index:
0
机构:
WELLCOME RES LABS,PHARMACOL LAB,BECKENHAM BR3 3BS,KENT,ENGLAND
WELLCOME RES LABS,PHARMACOL LAB,BECKENHAM BR3 3BS,KENT,ENGLAND
ARMSTRON.JM
BOURA, ALA
论文数:
0
引用数:
0
h-index:
0
机构:
WELLCOME RES LABS,PHARMACOL LAB,BECKENHAM BR3 3BS,KENT,ENGLAND
WELLCOME RES LABS,PHARMACOL LAB,BECKENHAM BR3 3BS,KENT,ENGLAND
BOURA, ALA
[J].
BRITISH JOURNAL OF PHARMACOLOGY,
1973,
47
(04)
: 850
-
852
[3]
DOCHERTY JP, UNPUBLISHED
[4]
SYMPATHOMIMETIC EFFECTS OF PANCURONIUM-BROMIDE ON CARDIOVASCULAR-SYSTEM OF PITHED RAT - COMPARISON WITH EFFECTS OF DRUGS BLOCKING NEURONAL UPTAKE OF NORADRENALINE
DOCHERTY, JR
论文数:
0
引用数:
0
h-index:
0
DOCHERTY, JR
MCGRATH, JC
论文数:
0
引用数:
0
h-index:
0
MCGRATH, JC
[J].
BRITISH JOURNAL OF PHARMACOLOGY,
1978,
64
(04)
: 589
-
599
[5]
DOCHERTY JR, 1977, J PHYSIOL-LONDON, V273, pP63
[6]
DOCHERTY JR, 1977, BRIT J PHARMACOL, V61, pP472
[7]
DOCHERTY JR, 1978, BRIT J PHARMACOL, V64, pP419
[8]
AN ANALYSIS OF SOME FACTORS INFLUENCING ALPHA-ADRENOCEPTOR FEEDBACK AT THE SYMPATHETIC JUNCTION IN THE RAT-HEART
DOCHERTY, JR
论文数:
0
引用数:
0
h-index:
0
机构:
Institute of Physiology, University of Glasgow, Glasgow
DOCHERTY, JR
MCGRATH, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Institute of Physiology, University of Glasgow, Glasgow
MCGRATH, JC
[J].
BRITISH JOURNAL OF PHARMACOLOGY,
1979,
66
(01)
: 55
-
63
[9]
EFFECT OF CLONIDINE ON CARDIAC ACCELERATION IN PITHED RATS
DOXEY, JC
论文数:
0
引用数:
0
h-index:
0
机构:
RECKITT & COLMAN LTD,DIV PHARMACEUT,HULL HU8 7DS,ENGLAND
RECKITT & COLMAN LTD,DIV PHARMACEUT,HULL HU8 7DS,ENGLAND
DOXEY, JC
[J].
JOURNAL OF PHARMACY AND PHARMACOLOGY,
1977,
29
(03)
: 173
-
174
[10]
EFFECTS OF ALPHA-ADRENOCEPTOR AGONISTS AND ANTAGONISTS ON PRE-SYNAPTICALLY AND POSTSYNAPTICALLY LOCATED ALPHA-ADRENOCEPTORS
DREW, GM
论文数:
0
引用数:
0
h-index:
0
机构:
ALLEN & HANBURYS RES LTD,DEPT PHARMACOL,WARE SG1I ODJ,HERTFORDSHIRE,ENGLAND
ALLEN & HANBURYS RES LTD,DEPT PHARMACOL,WARE SG1I ODJ,HERTFORDSHIRE,ENGLAND
DREW, GM
[J].
EUROPEAN JOURNAL OF PHARMACOLOGY,
1976,
36
(02)
: 313
-
320
←
1
2
3
→