PLASMA GSH GSSG AFFECTS GLUCOSE-HOMEOSTASIS IN HEALTHY-SUBJECTS AND NON-INSULIN-DEPENDENT DIABETICS

被引:93
作者
PAOLISSO, G
DIMARO, G
PIZZA, G
DAMORE, A
SGAMBATO, S
TESAURO, P
VARRICCHIO, M
DONOFRIO, F
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 263卷 / 03期
关键词
INSULIN SECRETION; INSULIN ACTION; TOTAL GLUCOSE DISPOSAL; OXIDATIVE GLUCOSE METABOLISM; NONOXIDATIVE GLUCOSE METABOLISM; MEMBRANE MICROVISCOSITY; REDUCED OXIDIZED GLUTATHIONE RATIO;
D O I
10.1152/ajpendo.1992.263.3.E435
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
In healthy subjects (n = 10) and non-insulin-dependent (type II) diabetics (n = 10) matched for age [43.1 +/- 2.2 vs. 41 +/- 4.4 yr, P = not significant (NS)], body mass index (25.1 +/- 1.1 vs. 26 +/- 0.8 kg/m2, P = NS), gender ratio [5 males (M)/5 females (F) vs. 5M/5F], and mean arterial blood pressure (105 +/- 7 vs. 106 +/- 9 mmHg, P = NS), we determined the changes in insulin secretion and action after glutathione infusion (15 mg/min) and the relative increase in the plasma reduced (GSH)/oxidized (GSSG) glutathione ratio. The rise in the plasma GSH/GSSG ratio significantly improved total body glucose disposal in healthy subjects and in diabetic patients. In this latter group, GSH infusion potentiated the beta-cell response to glucose slightly. In controls and diabetics, insulin infusion with a simultaneous increase in the plasma GSH/GSSG ratio significantly enhanced nonoxidative glucose disposal without affecting oxidative glucose metabolism. After glutathione infusion, all metabolic and hormonal changes correlated with a significant decline in plasma membrane microviscosity. In conclusion, the plasma GSH/GSSG ratio seems to play a major role in the modulation of glucose homeostasis mainly in diabetics.
引用
收藏
页码:E435 / E440
页数:6
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