NOVEL VAGINAL DRUG-RELEASE APPLICATIONS

被引:50
作者
BRANNONPEPPAS, L
机构
[1] Biogel Technology, Indianapolis, IN
关键词
VAGINAL RINGS; PESSARIES; BIOADHESIVE; TABLET; MICROPARTICLE;
D O I
10.1016/0169-409X(93)90031-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A review is presented of types of vaginal drug delivery systems, both in commercial use and in research. The few delivery systems that do exist are usually used for contraception or to treat vaginal infections. Commercially available vaginal ring delivery systems are usually based upon silicone elastomers while pessaries (tablets or suppositories) are usually dissolving systems utilizing a variety of materials. The future of vaginal drug delivery lies in the bioadhesive tablets and microparticles which, although relatively new, show great promise in providing truly controlled delivery for more than just the few hours that current formulations can offer. The use of hydrogels such as poly(acrylic acid) and celluloses in these systems is critical because it supplies the bioadhesive nature of the formulations.
引用
收藏
页码:169 / 177
页数:9
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