LURIA-DELBRUCK FLUCTUATION ANALYSIS - ESTIMATING THE POISSON PARAMETER IN A COMPOUND POISSON-DISTRIBUTION

被引：13

作者：

JONES, ME ^{[1
]}

WHELDRAKE, J ^{[1
]}

ROGERS, A ^{[1
]}

机构：

[1] FLINDERS UNIV S AUSTRALIA,SCH BIOL SCI,BEDFORD PK,SA 5042,AUSTRALIA

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 1993年 / 23卷 / 06期

关键词：

LURIA-DELBRUCK; FLUCTUATION ANALYSIS; MAXIMUM LIKELIHOOD ESTIMATOR; PARAMETER; ESTIMATION; MUTATION; COMPOUND POISSON DISTRIBUTION; DISCRETE CONVOLUTION;

D O I：

10.1016/0010-4825(93)90099-M

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Estimating the mutation rate from a Luria-Delbruck fluctuation experiment involves estimating the Poisson parameter in a compound Poisson distribution. The efficiency with which this can be estimated depends on how well the other random factors have been characterized. The assumption that cell growth can be represented as a stochastic pure birth or Yule process is biologically unrealistic but contributes little to the bias and variance of a maximum likelihood estimator of the mutation rate.

引用

页码：525 / 534

页数：10

共 17 条

[1]

[Anonymous], 1991, MINITAB REFERENCE MA

[2]

ARMITAGE P, 1952, J ROY STAT SOC B, V14, P1

[3] THE ORIGIN OF MUTANTS [J].

CAIRNS, J ;

OVERBAUGH, J ;

MILLER, S .

NATURE, 1988, 335 (6186) :142-145

[4]

CHU EHY, 1969, GENETICS, V62, P359

[5]

Feller W., 1968, INTRO PROBABILITY TH, V1st

[6]

FORD DK, 1958, J NATL CANCER I, V21, P393

[7] MUTATION RATES IN CELLS AT DIFFERENT PLOIDY LEVELS [J].

HARRIS, M .

JOURNAL OF CELLULAR PHYSIOLOGY, 1971, 78 (02) :177-&

[8]

KARLIN S, 1966, 1ST COURS STOCH PROC, P180

[9]

KENDAL WS, 1988, CANCER RES, V48, P1060

[10]

KNUTH DE, 1981, ART COMPUTER PROGRAM, V2, P25

← 1 2 →