V(D)J RECOMBINATION GETS A BREAK

被引：38

作者：

GELLERT, M

机构：

来源：

TRENDS IN GENETICS | 1992年 / 8卷 / 12期

关键词：

D O I：

10.1016/0168-9525(92)90322-U

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The diversity of immunoglobulins and T cell receptors is largely due to the assembly of functional genes from separate segments. The mechanism by which these gene fragments are joined is starting to be deciphered, with broken DNA molecules that may be intermediates in the reaction providing a new clue.

引用

页码：408 / 412

页数：5

共 35 条

[1] SCID MUTATION IN MICE CONFERS HYPERSENSITIVITY TO IONIZING-RADIATION AND A DEFICIENCY IN DNA DOUBLE-STRAND BREAK REPAIR
BIEDERMANN, KA
SUN, JR
GIACCIA, AJ
TOSTO, LM
BROWN, JM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1394 - 1397
[2] Blackwell T. K., 1988, Molecular Immunology., P1
[3] ISOLATION OF SCID PRE-B CELLS THAT REARRANGE KAPPA-LIGHT CHAIN GENES - FORMATION OF NORMAL SIGNAL AND ABNORMAL CODING JOINS
BLACKWELL, TK
MALYNN, BA
POLLOCK, RR
FERRIER, P
COVEY, LR
FULOP, GM
PHILLIPS, RA
YANCOPOULOS, GD
ALT, FW
[J]. EMBO JOURNAL, 1989, 8 (03) : 735 - 742
[4] A SEVERE COMBINED IMMUNODEFICIENCY MUTATION IN THE MOUSE
BOSMA, GC
CUSTER, RP
BOSMA, MJ
[J]. NATURE, 1983, 301 (5900) : 527 - 530
[5] ISOLATION AND CHARACTERIZATION OF HUMAN CDNA CLONES ENCODING A HIGH MOBILITY GROUP BOX PROTEIN THAT RECOGNIZES STRUCTURAL DISTORTIONS TO DNA CAUSED BY BINDING OF THE ANTICANCER AGENT CISPLATIN
BRUHN, SL
PIL, PM
ESSIGMANN, JM
HOUSMAN, DE
LIPPARD, SJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) : 2307 - 2311
[6] CHEN JW, 1992, CELL, V69, P674
[7] TRANSPOSABLE ELEMENTS GENERATE NOVEL SPATIAL PATTERNS OF GENE-EXPRESSION IN ANTIRRHINUM MAJUS
COEN, ES
CARPENTER, R
MARTIN, C
[J]. CELL, 1986, 47 (02) : 285 - 296
[8] A STRAIN-SPECIFIC MODIFIER ON MOUSE CHROMOSOME-4 CONTROLS THE METHYLATION OF INDEPENDENT TRANSGENE LOCI
ENGLER, P
HAASCH, D
PINKERT, CA
DOGLIO, L
GLYMOUR, M
BRINSTER, R
STORB, U
[J]. CELL, 1991, 65 (06) : 939 - 947
[9] THE SCID MUTATION IN MICE CAUSES A GENERAL DEFECT IN DNA-REPAIR
FULOP, GM
PHILLIPS, RA
[J]. NATURE, 1990, 347 (6292) : 479 - 482
[10] SEQUENCE HOMOLOGIES, N-SEQUENCE INSERTION AND JH GENE UTILIZATION IN VHDJH JOINING - IMPLICATIONS FOR THE JOINING MECHANISM AND THE ONTOGENIC TIMING OF LY1-B CELL AND B-CLL PROGENITOR GENERATION
GU, H
FORSTER, I
RAJEWSKY, K
[J]. EMBO JOURNAL, 1990, 9 (07) : 2133 - 2140

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