TC-99M-LABELED POLYCLONAL HUMAN IMMUNOGLOBULIN-G SCINTIGRAPHY BEFORE AND AFTER INTRAARTICULAR KNEE INJECTION OF TRIAMCINOLONE HEXACETONIDE IN PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：37

作者：

DEBOIS, MHW

ARNDT, JW

TAK, PP

KLUIN, PM

VANDERVELDE, EA

PAUWELS, EKJ

BREEDVELD, FC

机构：

[1] Departments of Rheumatology, University Hospital, Leiden

[2] Departments of Diagnostic Radiology and Nuclear Medicine, University Hospital, Leiden

[3] Departments of Internal Medicine, University Hospital, Leiden

[4] Departments of Pathology, University Hospital, Leiden

[5] Departments of Medical Statistics, University Hospital, Leiden

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1993年 / 14卷 / 10期

关键词：

D O I：

10.1097/00006231-199310000-00009

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The ability of Tc-99m-labelled polyclonal human immunoglobulin G (Tc-99m-IgG) scintigraphy to monitor intra-individual variation in arthritis activity was studied in seven patients with rheumatoid arthritis (RA). These patients were treated with an intra-articular injection of 20 mg triamcinolone hexacetonide. The results of semiquantitative Tc-99m-IgG scintigraphy were compared with the degree of joint swelling and the histological changes observed in synovial biopsies before and 14 days after the injection. In all seven patients the local treatment resulted in a decreased arthritis activity of the treated knee as measured clinically or histologically. This decrease was parallelled, in all patients except one, by a lower uptake of Tc-99m-IgG after the injection when compared to uptake prior to treatment. This study shows that Tc-99m-IgG scintigraphy is able to reflect intra-individual variations in arthritis activity in patients with RA.

引用

页码：883 / 887

页数：5

共 27 条

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