HLA-DPB1 GLUTAMATE-69 - A GENETIC-MARKER OF BERYLLIUM DISEASE

被引：360

作者：

RICHELDI, L

SORRENTINO, R

SALTINI, C

机构：

[1] UNIV ROME, POSTGRAD SCH CARDIORESP PHYSIOPATHOL, I-00100 ROME, ITALY

[2] UNIV MODENA, INST TB & RESP DIS, USL 16, I-41100 MODENA, ITALY

[3] UNIV LAQUILA, DEPT EXPTL MED, I-67100 LAQUILA, ITALY

[4] UNIV ROMA LA SAPIENZA, DEPT CELLULAR & DEV BIOL, I-00185 ROME, ITALY

来源：

SCIENCE | 1993年 / 262卷 / 5131期

关键词：

D O I：

10.1126/science.8105536

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic beryllium disease (CBD) is a lung disorder related to beryllium exposure and is characterized by the accumulation in the lung of beryllium-specific CD4+ major histocompatibility complex (MHC) class II-restricted T lymphocytes. Evaluation of MHC class II genes in 33 CBD cases and 44 controls has shown a negative association with HLA-DPB1*0401 (P < 0.001) and a positive association with HLA-DPB1*0201 (P < 0.05) alleles, which differ at residues 36, 55 to 56, and 69 of the beta1 chain. Among CBD cases, 97 percent expressed the HLA-DPB1*0201-associated glutamic acid (unaffected population, 30 percent; P < 0.001) at residue 69, a position involved in susceptibility to autoimmune disorders. This suggests that HLA-DP has a role in conferring susceptibility and that residue 69 of HLA-DPB1 could be used in risk assessment for CBD.

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页码：242 / 244

页数：3

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