CLONING AND EXPRESSION OF THE CHICKEN CD18 CDNA

被引：13

作者：

BILSLAND, CAG

SPRINGER, TA

机构：

[1] HARVARD UNIV, CTR BLOOD RES, SCH MED, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1994年 / 55卷 / 04期

关键词：

LFA-1; CHICKEN CD18 CDNA; LEUKOCYTE INTEGRINS;

D O I：

10.1002/jlb.55.4.501

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The leukocyte integrins play a critical role in a number of cellular adhesive interactions during the immune response. We describe here the isolation and characterization of the chicken beta 2 (CD18) subunit, common to the leukocyte integrin family. The deduced 748-amino-acid sequence reveals a transmembrane protein with 65% and 64% identity with its human and murine homologues, respectively. The chicken beta 2 can associate on the cell surface with the human alpha subunit of LFA-1 and yields a hybrid molecule capable of binding to purified ICAM-1 and ICAM-3.

引用

页码：501 / 506

页数：6

共 43 条

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