TRANSLATIONAL CONTROL OF CYTOKINE EXPRESSION BY 3' UA-RICH SEQUENCES

被引：48

作者：

KRUYS, V

HUEZ, G

机构：

[1] Laboratoire de Chimie Biologique, Département de Biologie Moléculaire, Université Libre de Bruxelles, 1640 Rhode-Saint-Genèse, 67, rue des Chevaux

来源：

BIOCHIMIE | 1994年 / 76卷 / 09期

关键词：

POSTTRANSCRIPTIONAL REGULATION; RNA MESSENGER; TRANSLATIONAL EFFICIENCY;

D O I：

10.1016/0300-9084(94)90188-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several messenger RNAs which are transiently expressed contain a conserved uridine-adenosine-rich sequence in their 3' untranslated region. Many of these mRNAs encode cytokines, growth factors or oncoproteins. This UA-rich sequence is composed of several interspersed repeats of the octanucleotide UUAUUUAU and plays a key role in the post-transcriptional regulation of these mRNAs. Known as instability determinants, these UA-rich elements can also strongly affect mRNA translational regulation and give insight into the underlying mechanism.

引用

页码：862 / 866

页数：5

共 33 条

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