THE ORDER AND ORIENTATION OF A CLUSTER OF METALLOPROTEINASE GENES, STROMELYSIN-2, COLLAGENASE, AND STROMELYSIN, TOGETHER WITH D11S385, ON CHROMOSOME-11Q22-Q23

被引：25

作者：

FORMSTONE, CJ

BYRD, PJ

AMBROSE, HJ

RILEY, JH

HERNANDEZ, D

MCCONVILLE, CM

TAYLOR, AMR

机构：

[1] UNIV BIRMINGHAM,SCH MED,CANC RES CAMPAIGN LABS,DEPT CANC STUDIES,POB 363,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[2] ICI PLC,PHARMACEUT,DEPT BIOTECHNOL,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

GENOMICS | 1993年 / 16卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1181

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A cluster of metalloproteinase genes, stromelysin, fibroblast collagenase, and stromelysin 2 together with the anonymous DNA marker D11S385, was mapped using pulsed-field gel electrophoresis to a 135-kb region of chromosome 11q22-q23. The physical proximity of these markers was subsequently confirmed using two YAC clones, and their relative order was established as stromelysin 2-collagenase-stromelysin-D11S385. The pattern of marker representation in a panel of radiation-reduced chromosome 11 hybrids suggests that the metalloproteinase gene/D11S385 cluster is orientated with STMY2 closest to the centromere. © 1993 by Academic Press, Inc.

引用

页码：289 / 291

页数：3

共 11 条

[1]

COLLIER IE, 1988, J BIOL CHEM, V263, P10711

[2] SEGREGATION OF THE HUNTINGTON DISEASE REGION OF HUMAN-CHROMOSOME 4 IN A SOMATIC-CELL HYBRID [J].

COX, DR ;

PRITCHARD, CA ;

UGLUM, E ;

CASHER, D ;

KOBORI, J ;

MYERS, RM .

GENOMICS, 1989, 4 (03) :397-407

[3] LOCALIZATION OF AN ATAXIA-TELANGIECTASIA GENE TO CHROMOSOME 11Q22-23 [J].

GATTI, RA ;

BERKEL, I ;

BODER, E ;

BRAEDT, G ;

CHARMLEY, P ;

CONCANNON, P ;

ERSOY, F ;

FOROUD, T ;

JASPERS, NGJ ;

LANGE, K ;

LATHROP, GM ;

LEPPERT, M ;

NAKAMURA, Y ;

OCONNELL, P ;

PATERSON, M ;

SALSER, W ;

SANAL, O ;

SILVER, J ;

SPARKES, RS ;

SUSI, E ;

WEEKS, DE ;

WEI, S ;

WHITE, R ;

YODER, F .

NATURE, 1988, 336 (6199) :577-580

[4] A DETAILED GENETIC-MAP OF THE LONG ARM OF CHROMOSOME-11 [J].

JULIER, C ;

NAKAMURA, Y ;

LATHROP, M ;

OCONNELL, P ;

LEPPERT, M ;

LITT, M ;

MOHANDAS, T ;

LALOUEL, JM ;

WHITE, R .

GENOMICS, 1990, 7 (03) :335-345

[5]

JUNG JY, 1990, ANN GENET-PARIS, V33, P21

[6] GENETICS OF SOMATIC MAMMALIAN-CELLS .20. GENETICS OF SOMATIC MAMMALIAN-CELLS - GENETIC, IMMUNOLOGICAL, AND BIOCHEMICAL ANALYSIS WITH CHINESE-HAMSTER CELL HYBRIDS CONTAINING SELECTED HUMAN CHROMOSOMES [J].

KAO, FT ;

JONES, C ;

PUCK, TT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (01) :193-197

[7] FINE MAPPING OF THE CHROMOSOME-11Q22-23 REGION USING PFGE, LINKAGE AND HAPLOTYPE ANALYSIS - LOCALIZATION OF THE GENE FOR ATAXIA TELANGIECTASIA TO A 5CM REGION FLANKED BY NCAM/DRD2 AND STMY/CJ52.75, PHI-2.22 [J].

MCCONVILLE, CM ;

FORMSTONE, CJ ;

HERNANDEZ, D ;

THICK, J ;

TAYLOR, AMR .

NUCLEIC ACIDS RESEARCH, 1990, 18 (15) :4335-4343

[8] THE COLLAGENASE GENE FAMILY IN HUMANS CONSISTS OF AT LEAST 4 MEMBERS [J].

MULLER, D ;

QUANTIN, B ;

GESNEL, MC ;

MILLONCOLLARD, R ;

ABECASSIS, J ;

BREATHNACH, R .

BIOCHEMICAL JOURNAL, 1988, 253 (01) :187-192

[9] CLONING OF THE GENES FOR HUMAN STROMELYSIN AND STROMELYSIN .2. DIFFERENTIAL EXPRESSION IN RHEUMATOID SYNOVIAL FIBROBLASTS [J].

SIRUM, KL ;

BRINCKERHOFF, CE .

BIOCHEMISTRY, 1989, 28 (22) :8691-8698

[10]

SOBEL E, 1992, AM J HUM GENET, V50, P1343

← 1 2 →