IRON ACQUISITION FROM HEME AND HEMOGLOBIN BY A SERRATIA-MARCESCENS EXTRACELLULAR PROTEIN

被引：167

作者：

LETOFFE, S

GHIGO, JM

WANDERSMAN, C

机构：

[1] U. de Physiologie Cellulaire, Ctr. Natl. de la Rech. Scientifique, U. de Rech. Associee 1300, 75724 Paris Cedex 15

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 21期

关键词：

ABC TRANSPORTER; HEME-BINDING PROTEIN;

D O I：

10.1073/pnas.91.21.9876

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several pathogenic bacteria are able to use heme and hemoproteins as iron sources independent of siderophore production by mechanisms involving outer membrane heme-binding proteins and heme transport systems. Here we show that Serratia marcescens has such a property and we identify an extracellular heme-binding protein, HasA (for heme acquisition system), allowing the release of heme from hemoglobin. This protein is secreted by S. marcescens under conditions of iron depletion and is essential for heme acquisition.

引用

页码：9876 / 9880

页数：5

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