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SYNTHESIS AND CHARACTERIZATION OF (D)NTP DERIVATIVES SUBSTITUTED WITH RESIDUES OF DIFFERENT PHOTOREAGENTS

被引：54
作者：
WLASSOFF, WA
DOBRIKOV, MI
SAFRONOV, IV
DUDKO, RY
BOGACHEV, VS
KANDAUROVA, VV
SHISHKIN, GV
DYMSHITS, GM
LAVRIK, OI
机构：
[1] RUSSIAN ACAD SCI,INST ORGAN CHEM,NOVOSIBIRSK 630090,RUSSIA
[2] RUSSIAN ACAD SCI,NOVOSIBIRSK INST BIOORGAN CHEM,NOVOSIBIRSK 630090,RUSSIA
来源：
BIOCONJUGATE CHEMISTRY | 1995年 / 6卷 / 04期
关键词：
D O I：
10.1021/bc00034a003
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemical cross-linking agents having a photoactivable azido group are promising for the study of the spatial organization of biopolymers. We describe here a variety of (d)NTPs derivatives (6a, 6b, 7, 11, 12, 14, and 16) bearing the residues of three different photoreagents containing an aromatic azido group (1a, 2a, and 3a). These conjugates provide a wide choice of instruments to investigate nucleic acid-nucleic acid and nucleic acid-protein interaction. The synthesis of new photoreagent 2a has been also fulfilled. This compound is the most attractive for affinity modification of the nucleic acids.
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页码：352 / 360
页数：9
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